Proceedings of the National Academy of Sciences of the United States of America

Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model.

Proceedings of the National Academy of Sciences of the United States of America

Yin M, Smith JA, Chou M, Chan J, Jittayasothorn Y, Gould DB, Caspi RR, Anderson MS, DeFranco AL

Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.

Proceedings of the National Academy of Sciences of the United States of America

Bennett NK, Lee M, Orr AL, Nakamura K

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer.

Proceedings of the National Academy of Sciences of the United States of America

Wang S, Böhnert V, Joseph AJ, Sudaryo V, Skariah G, Swinderman JT, Yu FB, Subramanyam V, Wolf DM, Lyu X, Gilbert LA, Van't Veer LJ, Goodarzi H, Li L

Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.

Proceedings of the National Academy of Sciences of the United States of America

Caruso JA, Wang X, Murrow LM, Rodriguez CI, Chen-Tanyolac C, Vu L, Chen YY, Gascard P, Gartner ZJ, Kerlikowske K, Tlsty TD

Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.

Proceedings of the National Academy of Sciences of the United States of America

Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson AB, Silm K, Ford CP, Edwards RH

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.

Proceedings of the National Academy of Sciences of the United States of America

Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS

A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.

Proceedings of the National Academy of Sciences of the United States of America

Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS

PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease.

Proceedings of the National Academy of Sciences of the United States of America

Thakore P, Yamasaki E, Ali S, Sanchez Solano A, Labelle-Dumais C, Gao X, Chaumeil MM, Gould DB, Earley S

Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation.

Proceedings of the National Academy of Sciences of the United States of America

Sheppard PAS, Chandramohan D, Lumsden A, Vellone D, Denley MCS, Srivastava DP, Choleris E

T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America

Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS

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