Proceedings of the National Academy of Sciences of the United States of America

Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA.

Proceedings of the National Academy of Sciences of the United States of America

Andrabi SBA, Kalim UU, Palani S, Khan MM, Khan MH, Fagersund J, Orpana J, Paulin N, Batkulwar K, Junttila S, Buchacher T, Grönroos T, Toikka L, Ammunet T, Sen P, Orešic M, Kumpulainen V, Tuomisto JEE, Sinha R, Marson A, Rasool O, Elo LL, Lahesmaa R

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes.

Proceedings of the National Academy of Sciences of the United States of America

Rose K, Jepson T, Shukla S, Maya-Romero A, Kampmann M, Xu K, Hurley JH

CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling.

Proceedings of the National Academy of Sciences of the United States of America

Halasz H, Malekos E, Covarrubias S, Yitiz S, Montano C, Sudek L, Katzman S, Liu SJ, Horlbeck MA, Namvar L, Weissman JS, Carpenter S

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.

Proceedings of the National Academy of Sciences of the United States of America

Liang XG, Hoang K, Meyerink BL, Kc P, Paraiso K, Wang L, Jones IR, Zhang Y, Katzman S, Finn TS, Tsyporin J, Qu F, Chen Z, Visel A, Kriegstein A, Shen Y, Pilaz LJ, Chen B

Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.

Proceedings of the National Academy of Sciences of the United States of America

Goyette MA, Stevens LE, DePinho CR, Seehawer M, Nishida J, Li Z, Wilde CM, Li R, Qiu X, Pyke AL, Zhao S, Lim K, Tender GS, Northey JJ, Riley NM, Long HW, Bertozzi CR, Weaver VM, Polyak K

Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones.

Proceedings of the National Academy of Sciences of the United States of America

Smith JA, Yuen BTK, Purtha W, Balolong JM, Phipps JD, Crawford F, Bluestone JA, Kappler JW, Anderson MS

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Proceedings of the National Academy of Sciences of the United States of America

Sachdev A, Gill K, Sckaff M, Birk AM, Aladesuyi Arogundade O, Brown KA, Chouhan RS, Issagholian-Lewin PO, Patel E, Watry HL, Bernardi MT, Keough KC, Tsai YC, Smith AST, Conklin BR, Clelland CD

Diverse roles of pontine NPS-expressing neurons in sleep regulation.

Proceedings of the National Academy of Sciences of the United States of America

Xing L, Zou X, Yin C, Webb JM, Shi G, Ptácek LJ, Fu YH

Phase separation of YAP-MAML2 differentially regulates the transcriptome.

Proceedings of the National Academy of Sciences of the United States of America

Chung CI, Yang J, Yang X, Liu H, Ma Z, Szulzewsky F, Holland EC, Shen Y, Shu X

The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.

Proceedings of the National Academy of Sciences of the United States of America

Leon WRM, Steffen DM, Dale-Huang FR, Rakela B, Breevoort A, Romero-Rodriguez R, Hasenstaub AR, Stryker MP, Weiner JA, Alvarez-Buylla A

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