Proceedings of the National Academy of Sciences of the United States of America

Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.

Proceedings of the National Academy of Sciences of the United States of America

Zhou J, Li S, Leung KK, O'Donovan B, Zou JY, DeRisi JL, Wells JA

ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense.

Proceedings of the National Academy of Sciences of the United States of America

Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.

Proceedings of the National Academy of Sciences of the United States of America

Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG

Dark noise and retinal degeneration from D190N-rhodopsin.

Proceedings of the National Academy of Sciences of the United States of America

Silverman D, Chai Z, Yue WWS, Ramisetty SK, Bekshe Lokappa S, Sakai K, Frederiksen R, Bina P, Tsang SH, Yamashita T, Chen J, Yau KW

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Ramesh A, Schubert RD, Greenfield AL, Dandekar R, Loudermilk R, Sabatino JJ, Koelzer MT, Tran EB, Koshal K, Kim K, Pröbstel AK, Banerji D

Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.

Proceedings of the National Academy of Sciences of the United States of America

White CW, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA

Sequence-independent recognition of the amyloid structural motif by GFP protein family.

Proceedings of the National Academy of Sciences of the United States of America

Xu SCS, LoRicco JG, Bishop AC, James NA, Huynh WH, McCallum SA, Roan NR, Makhatadze GI

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.

Proceedings of the National Academy of Sciences of the United States of America

Damas J, Hughes GM, Keough KC, Painter CA, Persky NS, Corbo M, Hiller M, Koepfli KP, Pfenning AR, Zhao H, Genereux DP, Swofford R, Pollard KS, Ryder OA, Nweeia MT, Lindblad-Toh K, Teeling EC, Karlsson EK, Lewin HA

A robust and interpretable end-to-end deep learning model for cytometry data.

Proceedings of the National Academy of Sciences of the United States of America

Hu Z, Tang A, Singh J, Bhattacharya S, Butte AJ

MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Sangokoya C, Blelloch R

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