We study T cell immunity to tuberculosis (TB). In mice, we characterize mechanisms of CD4 T cell evasion in TB, and we study humans to discover mechanisms that provide protective immunity to TB that can be improved by vaccines.
Mechanisms of signaling and trafficking at the primary cilium, biogenesis of extracellular vesicles.
Mentorship Development:
12/19/19 ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
12/8/20 Setting Expectations with a "Welcome to the Lab' Letter (Parts 1 and 2)
Our program explores the impact of metabolic stress on deregulated micro-RNA controlled hematopoiesis and immune cell function in the pathogenesis of atherosclerosis, including through intercellular signaling via exosomes
We study how genetic changes that accumulated over the last 6 million years of human evolution influence specialized features of brain development using single cell genomics, cerebral organoid models of ape brain development, and genome engineering.
Early stages of development of neurodegenerative diseases in humans. Dr. Grinberg employs a combination of well characterized postmortem human brain tissue, Neurons derived from IPSc lines and advanced methods of imaging processing.
We study how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury.
Genomic instability and DNA repair in neural cells
Mentorship Development:
4/11/19 Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
12/19/19 ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
3/10/20 Promoting Student Mental Health:A Presentation and Discussion (Staff and Faculty)
4/30/20 Mental Health in a Pandemic: Q&A for Faculty
10/20/20 Gathering in Community: a Training for Faculty and Staff
Our lab applies single-cell analysis approaches on in vitro and clinical specimens to study the interplay between immune cells & viral pathogens including HIV & SARS-CoV-2, & to study the properties of immune cells in mucosal tissues in health & disease