Erin Gordon, MD

Assistant Professor

Medicine

+1 415 476-9456

Research Description:

I am a physician-scientist with an interest in airway epithelial dysfunction in asthma. Specifically, my lab focuses on understanding how genetic risk variants that are associated with asthma at a population level, actually confer risk of disease at a molecular level. We use novel techniques such as conditionally reprogrammed primary airway epithelial cells, CRISPR gene deletion, and biospecimens from large numbers of human subjects to discover the function of genes associated with asthma and elucidate the causal single nucleotide polymorphism. These efforts are designed to uncover novel drug targets and define the subpopulation of asthmatics most likely to benefit from therapy.

Primary Thematic Area:

Human Genetics

Secondary Thematic Area:

Immunology

Research Summary:

Determine the molecular mechanisms and causal variants of asthma-associated genetic loci.

Publications:

A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.

Nature communications

Everman JL, Sajuthi SP, Liegeois MA, Jackson ND, Collet EH, Peters MC, Chioccioli M, Moore CM, Patel BB, Dyjack N, Powell R, Rios C, Montgomery MT, Eng C, Elhawary JR, Mak ACY, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen GL, Michel CR, Gomez J, Zhang X, Medina V, Chu HW, Cicuta P, Gordon ED, Zeitlin P, Ortega VE, Reisdorph N, Dunican EM, Tang M, Elicker BM, Henry TS, Bleecker ER, Castro M, Erzurum SC, Israel E, Levy BD, Mauger DT, Meyers DA, Sumino K, Gierada DS, Hastie AT, Moore WC, Denlinger LC, Jarjour NN, Schiebler ML, Wenzel SE, Woodruff PG, Rodriguez-Santana J, Pearson CG, Burchard EG, Fahy JV, Seibold MA

Erin Gordon, MD

A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.

Interleukin-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis.

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.

Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.

Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.

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Erin Gordon, MD

A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.

Interleukin-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis.

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.

Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.

Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.