2010-11 Schedule
Journal Club Chairs: Doug Gould, PhD and Mike German, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room GH-S271, Mission Bay
Web Stream is currently unavailable. To inquire about DVD recordings, please contact the BMS office.
September 8, 2010
Laura Simpson (student)
"The mystery unfolds: How misfolded CFTR is detected at the plasma membrane"
Okiyoneda T, et al. Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science. 2010 Aug 13;329(5993):805-10.
Coaches: Scott Oakes and Jeoung-Sook Shin
Andrei Goga (faculty)
"Monocytes 'Let it all hang out': Regulation of gene expression by secreted microRNAs"
Zhang Y, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010 Jul 9;39(1):133-44.
September 16, 2010
Eric Wang (student)
MicroRNA Sponge?: A potential new role for pseudogenes
Poliseno L, et al. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature. 2010; 465: 1033–1038.
Coaches: Robert Blelloch, Scott Oakes
Ray Swanson (faculty)
A drug to treat stroke: Is it "Mission accomplished," or Quixotic quest?
Tu W, et al. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell. 2010 Jan 22;140(2):222-34.
September 23, 2010
Brittany Anderton (student)
A Purpose for Recalled Eggs?
Saccheri F, et al. Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity. Sci Transl Med. 2010 Aug 11;2(44):44ra57.
Coaches: Larry Fong, Jeoung-Sook Shin, and Andrei Goga
David Pearce (faculty)
Disease resistance at the expense of disease predisposition: the example of nephropathy in African Americans
Genovese G, et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010; 329: 841-845.
September 30, 2010
Koy Saeteurn (student)
What would you get if PPARgamma lacked a P?
Choi JH, et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.Nature. 2010 Jul 22;466(7305):451-6
Coaches: Kaveh Ashrafi and Suneil Koliwad
Ralph Marcucio (faculty)
Mechanisms of genotype-phenotype correlation
Raj, A, et al. Variability in gene expression underlies incomplete penetrance. Nature. 2010; 463: 913-918
October 7, 2010
Lea Gemmel (student)
Going viral: viromics of healthy human gut microbiota
Reyes A, et al. Viruses in the fecal microbiota of monozygotic twins and their mothers. Nature.2010; 466: 334–338.
Coaches: Charles Chiu and Susan Lynch
Jacquelyn Maher (faculty)
Inflamed fat and insulin resistance: one size does not fit all
Herrero L, et al. Inflammation and adipose tissue macrophages in lipodystrophic mice. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):240-5. Epub 2009 Dec 10.
October 14, 2010
Siang Yun Ang (student)
Double TIP-ping: Dual roles of PTIP in class switch recombination
Daniel JA, et al. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science. 2010 Aug 20;329(5994):917-23.
Coaches: Matthias Wabl and James Cleaver
Robin Shaw (faculty)
Understanding cellular endocytosis without a cell
Wu M, et al. Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system. Nat Cell Biol. 2010 Sep;12(9):902-8.
October 21, 2010
Liz Krow-Lucal (student)
Spare a nickel for toll
Schmidt M, et al. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol. 2010 Sep;11(9):814-9.
Coaches: Tony DeFranco and Lewis Lanier
Ben Braun (faculty)
Smart Bombs for Cancer
Flaherty KT, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med.2010 Aug 26;363(9):809-19.
October 28, 2010
Mustapha Ali (student)
Meet the new alpha-tubulin acetyltransferase: Mec-17
Akella JS , et al. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010 Sep 9;467(7312):218-22.
Coaches: Diane Barber and Torsten Wittmann
Emmanuelle Passegue (faculty)
Home sweet home: the intricacy of the hematopoietic stem cell niche
Méndez-Ferrer S, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010 Aug 12;466(7308):829-34.
November 4, 2010
Liz Unger (student)
Daddy's Little Girl
Gregg C, et al. Sex-specific parent-of-origin allelic expression in the mouse brain. Science. 2010 Aug 6;329(5992):682-5.
Jeroen Roose (faculty)
Gut Stem Cell Going Dutch
Snippert HJ, et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 2010 Oct 1;143(1):134-44.
November 18, 2010
Si-Han Hai (student)
A fishing expedition: Role of IgT in mucosal immunity of teleost fish
Zhang YA, et al. IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nat Immunol. 2010 Sep;11(9):827-35.
Coaches: Mehrdad Matloubian and Tony DeFranco
Suzanne Noble (faculty)
Duking it out in the gut: how Salmonella uses the host against its bacterial competitors
Winter SE, et al. Gut inflammation provides a respiratory electron acceptor for Salmonella.Nature. 2010 Sep 23;467(7314):426-9.
November 25, 2010
No Journal Club
Thanksgiving Holiday
December 2, 2010
Caroline Tang (student)
Genetic Evolution of Metastatic Pancreatic Cancer
Yachida S, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer.Nature. 2010 Oct 28;467(7319):1114-7.
Coaches: Matthias Hebrok and Jason Cyster
December 9, 2010
Jonathan Russell (student)
The zombie gene: the really, really weird genetics of FSHD
Lemmers RJ et al. A unifying genetic model for facioscapulohumeral muscular dystrophy. Science. 2010 Sep 24;329(5999):1650-3. Epub 2010 Aug 19.
Coaches: Louis Ptacek and Ying-Hui Fu
Diana Laird (faculty)
Cell competition gets bloody
Bondar T, Medzhitov R. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell. 2010 Apr 2;6(4):309-22.
December 16, 23, & 30, 2010
No Journal Club
Winter Break
January 6, 2011
Megan Robblee (student)
Netting a receptor for fishy fats
Oh da Y, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010 Sep 3;142(5):687-98.
Coaches: Jackie Maher and Suneil Koliwad
January 13, 2011
Robert Hesse (student)
The search for the trigger of regeneration: could sodium be the answer?
Tseng AS, et al. Induction of vertebrate regeneration by a transient sodium current. J Neurosci. 2010 Sep 29;30(39):13192-200.
Coaches: Robin Shaw and Ophir Klein
Jim McKerrow (faculty)
Explaining Right to Left shifts in the non-political arena
Echtler K, et al. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med. 2010 Jan;16(1):75-82.
January 20, 2011
Cameron Pitt (student)
Granulocytes Leading the Way in Lung Metastasis
Kowanetz M, et al. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci USA. 2010 Nov 16.
Coaches: Neil Shah and Scott Kogan
Marco Conti (faculty)
Mechanisms of paternal and maternal X chromosome inactivation: a new twist in the battle of the sexes
Shin J, et al. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010 Oct 21;467(7318):977-81.
January 27, 2011
*Special Time - 5:00 p.m.*
Rob Bell (student)
Crossing The Brain-Blood Barrier: Evidence for Tumor-Derived Endothelial Cells
Ricci-Vitiani L, et al. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature. 2010 Dec 9;468(7325):824-8.
Coaches: Dan Lim and Rong Wang
Didier Stainier (faculty)
Cell reprogramming: separating the wheat from the chaff
Szabo E, et al. Direct conversion of human fibroblasts to
multilineage blood progenitors. Nature. 2010 Nov 25;468(7323):521-6.
February 3, 2011
Timothy Schmidt (student)
Feel the Burn: All Your UDPase Are Belong to Us
Fang M, et al. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell. 2010 Nov 24;143(5):711-24.
Coaches: Jeroen Roose and Davide Ruggero
Emin Maltepe (faculty)
Hypoxia is good for your brain
Mazumdar J, et al. O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol. 2010 Oct;12(10):1007-13.
February 10, 2011
*Special Time - 5:00 p.m.*
Brenda Han (student)
Bystander Cells Stand By to Repel Invaders
Kasper CA, et al. Cell-cell propagation of NF-κB transcription factor and MAP kinase activation
amplifies innate immunity against bacterial infection. Immunity. 2010 Nov 24;33(5):804-16.
Coaches: Anthony DeFranco and Matthew Krummel
Art Weiss (faculty)
Eat, Drink, and.... but if you have The Disease of Kings.... you will not be so Merry
Joosten LA, et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 2010 Nov;62(11):3237-48.
February 17, 2011
Samantha Bell (student)
Netting a mechanism for how statins might help phagocytes trap bacteria
Chow OA, et al. Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe. 2010 Nov 18;8(5):445-54.
Coaches: Tony DeFranco and Cliff Lowell
Robert Edwards (faculty)
Can Mitochondrial Depolarization Be a Good Thing?
Guzman JN, et al. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 2010 Dec 2;468(7324):696-700.
February 24, 2011
Joan Zape (student)
Endothelial Cells: Turning people Into Stone
Medici D, et al. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010 Dec;16(12):1400-6.
Coaches: Matt Springer and Ann Zovein
John Murnane (faculty)
Redundant Confusion
Zha S, et al. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13;469(7329):250-4.
March 3, 2011
Gabriel Reyes (student)
No one likes a third wheel: Targeting aneuploidy cells as a cancer therapeutic
Tang YC, et al. Identification of aneuploidy-selective antiproliferation compounds. Cell. 2011 Feb 18;144(4):499-512.
Coaches: Neil Shah and Andrew Leavitt
John Fahy (faculty)
Bitter ways to relax airway smooth muscle
Deshpande DA, et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med. 2010 Nov;16(11):1299-304.
March 10, 2011
Alexander Ramos (student)
RNAeye: Dicer1 Loss in Macular Degeneration
Kaneko H, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Feb 6.
Coaches: Daniel Lim and Erik Ullian
Susan Lynch (faculty)
Microbiota manipulation – not necessarily an intuitive process
Manichanh C, et al. Reshaping the gut microbiome with bacterial transplantation and antibiotic intake. Genome Res. 2010 Oct;20(10):1411-9.
March 17, 2011
Renee Rivas (student)
Better living through genetics: How to make fitter couch potatoes in mice
Boström P, et al. C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010 Dec 23;143(7):1072-83.
Coaches: Robin Shaw and Deepak Srivastava
Tony DeFranco (faculty)
Targeting AID to generate high quality antibodies
Nowak et al. The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nature Immunology 12: 160-166, February 2011.
March 24, 2011
No Journal Club
Cesar Chavez Day
March 31, 2011
Ryan Delgado (student)
Brown Phat: It’s so hot right now
Bartelt A, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011 Feb;17(2):200-5.
Coaches: Daniel Lim and Christian Vaisse
Imran Khan (student)
Catch me if you can: Novel enrichment of endogenous antigen-specific B cells
Pape KA, et al. Different B cell populations mediate early and late memory during an endogenous immune response. Science. 2011 Mar 4;331(6021):1203-7.
Coaches: Tony DeFranco and Mark Anderson
April 7, 2011
Andrea Cantu (student)
Saving Superman: Are we closer to an ES cell cure?
Pearl JI, et al. Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Cell Stem Cell. 2011 Mar 4;8(3):309-17.
Coaches: Jeff Bluestone and Brad Stohr
Jillian Varonin (student)
Fatty Brains: Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism
Suzuki R, et al. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab. 2010 Dec 1;12(6):567-79.
Coaches: Mike German and Allison Xu
April 14, 2011
Florie Charles (student)
Home is where the Paneth cells are
Sato T, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011 Jan 20;469(7330):415-8.
Coaches: Brad Stohr and Holger Willenbring
Marie La Russa (student)
HOTTIP lincRNA: boldly going where no lincRNA has gone before
Wang KC, et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature. 2011 Mar 20.
Coaches: Robert Blelloch and Michael McManus
April 21, 2011
Leslie Tong (student)
Mainline-your-brain Time: How context causes heroin addiction relapse
Bossert JM, et al. Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin. Nat Neurosci. 2011 Apr;14(4):420-2.
Coaches: Dorit Ron and Daniel Lim
Daniel Nguyen (student)
There Goes the Neighborhood: Next-Door Cancer Cells Get Evicted
Ohsawa S, et al. Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. Dev Cell. 2011 Mar 15;20(3):315-28.
Coaches: Todd Nystul and Jay Debnath
April 28, 2011
Benjamin Cohn (student)
Hey! Whose Side Are You On Anyway?: Metaproteogenomic Analysis of a Novel Virophage
Yau S, et al. Virophage control of antarctic algal host-virus dynamics. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6163-8.
Coaches: Melanie Ott and Charles Chiu
Vien Nguyen (student)
Beware the dark side of iPSCs: increased mutational load through reprogramming
Gore A, et al. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 3;471(7336):63-7.
Coaches: Jun Song and Miguel Ramalho-Santos
May 5, 2011
Nicole Stone (student)
The DL on HDL and moving miRNAs
Vickers KC, et al. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011 Apr;13(4):423-33.
Coaches: Deepak Srivastava and Robert Blelloch
Ivan Vujkovic-Cvijin (student)
Why did the macrophage cross the stroma?
Beatty GL, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 2011 Mar 25;331(6024):1612-6.
Coaches: Mike McCune and Larry Fong
May 12, 2011
Kevin Dumas (student)
DNA Medical Tourism: Heterochromatic DSBs Leave Town For Repair
Chiolo I, et al. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell. 2011 Mar 4;144(5):732-44.
Coaches: John Murnane and Brad Stohr
Viola Lam (student)
Crossed-Dressed Dendritic cells Turn on T cells
Wakim LM, et al. Cross-dressed dendritic cells drive memory CD8(+) T-cell activation after viral infection. Nature. 2011 Mar 31;471(7340):629-32.
Coaches: Mehrdad Matloubian and Larry Fong
May 19, 2011
Allyson Spence (student)
It's the circle of life: Beta cell style
Porat S, et al. Control of Pancreatic β Cell Regeneration by Glucose Metabolism. Cell Metab. 2011 Apr 6;13(4):440-9.
Coaches: Qizhi Tang and Scott Oakes
Miranda Broz (student)
Worming your way out of sepsis: a cure within parasite
Puneet P, et al. The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88. Nat Immunol. 2011 Apr;12(4):344-51.
Coaches: Averil Ma and Jay Debnath
May 26, 2011
Bevin English (student)
The Vector Infector: Engineering a Fungus to Kill Malaria in the Mosquito
Fang W, et al. Development of transgenic fungi that kill human malaria parasites in mosquitoes. Science. 2011 Feb 25;331(6020):1074-7.
Coaches: Phil Rosenthal and Anita Sil
Tali Mazor (student)
5hmC Hammer: U can't transcribe this
Pastor WA, et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature. 2011 May 8.
Coaches: Dan Lim and Robert Blelloch
June 2, 2011
Melissa Ruck (student)
Invasion of the Ligand Snatcher
Qureshi OS, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3.
Coaches: Michelle Hermiston and Qizhi Tang
Jordan Mar (student)
Step Aside 4G, There's a New Network on the Block
Dubey GP, et al. Intercellular nanotubes mediate bacterial communication. Cell. 2011 Feb 18;144(4):590-600.
Coaches: Anita Sil and Suzanne Noble
June 9, 2011
Anna Gillespie (student)
Out of the Darkness and into the Light: Putting Anxiety under Optogenetic Control in Mice
Tye KM, et al. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. 2011 Mar 17;471(7338):358-62.
Coaches: Anatol Kreitzer and Steve Hamilton