The Journal of clinical investigation

Leveraging microenvironmental synthetic lethalities to treat cancer.

The Journal of clinical investigation

Metcalf KJ, Alazzeh A, Werb Z, Weaver VM

Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.

The Journal of clinical investigation

Moslehi J, Lichtman AH, Sharpe AH, Galluzzi L, Kitsis RN

Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.

The Journal of clinical investigation

Daggubati V, Hochstetler J, Bommireddy A, Choudhury A, Krup AL, Choksi PK, Tong P, Li A, Xu L, Reiter JF, Raleigh DR

Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.

The Journal of clinical investigation

Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Hoover J, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger DT, Nakamura M, Lanier LL, Looney MR, Greenland JR

Lung megakaryocytes are immune modulatory cells.

The Journal of clinical investigation

Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders Ii J, Georas SN, Veazey JM, Madere F, Tesoro Santos L, Arne AM, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons CE, Metcalf Pate KA, McGrath KE, Palis J, Morrell C

Landscape of coordinated immune responses to H1N1 challenge in humans.

The Journal of clinical investigation

Rahil Z, Leylek R, Schürch CM, Chen H, Bjornson-Hooper Z, Christensen SR, Gherardini PF, Bhate SS, Spitzer MH, Fragiadakis GK, Mukherjee N, Kim N, Jiang S, Yo J, Gaudilliere B, Affrime M, Bock B, Hensley SE, Idoyaga J, Aghaeepour N, Kim K, Nolan GP, McIlwain DR

Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma.

The Journal of clinical investigation

Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada H

BETs that cover the spread from acquired to heritable heart failure.

The Journal of clinical investigation

Alexanian M, Haldar SM

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.

The Journal of clinical investigation

Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, Stashko C, Volmar K, Yeh JJ, Weaver VM, Wang ZJ, Tempero MA, Weichert W, Collisson EA

Complement activation on endothelium initiates antibody-mediated acute lung injury.

The Journal of clinical investigation

Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR

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