The Journal of clinical investigation

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.

The Journal of clinical investigation

Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, Hansen KC, Littlepage LE, Weaver VM

Everolimus improves the efficacy of dasatinib in PDGFRa-driven glioma.

The Journal of clinical investigation

Miklja Z, Yadav VN, Cartaxo RT, Siada R, Thomas CC, Cummings JR, Mullan B, Stallard S, Paul A, Bruzek AK, Wierzbicki K, Yang T, Garcia T, Wolfe I, Leonard M, Robertson PL, Garton HJ, Wahl DR, Parmar HA, Sarkaria JN, Kline C, Mueller S, Nicolaides T, Glasser C, Leary SES, Venneti S, Kumar-Sinha C, Chinnaiyan AM, Mody R, Pai MP, Phoenix TN, Marini BL, Koschmann C

Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.

The Journal of clinical investigation

Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.

The Journal of clinical investigation

Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM

Opportunities and challenges in using real-world data for health care.

The Journal of clinical investigation

Rudrapatna VA, Butte AJ

Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.

The Journal of clinical investigation

Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR

GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.

The Journal of clinical investigation

Cheng J, Klei LR, Hubel NE, Zhang M, Schairer R, Maurer LM, Klei HB, Kang H, Concel VJ, Delekta PC, Dang EV, Mintz MA, Baens M, Cyster JG, Parameswaran N, Thome M, Lucas PC, McAllister-Lucas LM

The 2019 Nobel Prize honors fundamental discoveries in hypoxia response.

The Journal of clinical investigation

Moslehi J, Rathmell WK

The mir181ab1 cluster promotes kras-driven oncogenesis and progression in lung and pancreas.

The Journal of clinical investigation

Valencia K, Erice O, Kostyrko K, Hausmann S, Guruceaga E, Thathireddy A, Flores NM, Sayles LC, Lee AG, Fragoso R, Sun TQ, Vallejo A, Roman M, Entrialgo-Cadierno R, Migueliz I, Razquin N, Fortes P, Lecanda F, Lu J, Ponz-Sarvise M, Chen CZ, Mazur PK, Sweet-Cordero EA, Vicent S

Cellular heterogeneity in brown adipose tissue.

The Journal of clinical investigation

Oguri Y, Kajimura S

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