The Journal of clinical investigation

Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity.

The Journal of clinical investigation

Deng Z, Law CS, Kurra S, Simchoni N, Shum AK

Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.

The Journal of clinical investigation

Schab A, Compadre A, Drexler R, Loeb M, Rodriguez K, Brill J, Harrington S, Sandoval C, Sanders B, Kuroki L, McCourt C, Hagemann AR, Thaker P, Mutch D, Powell M, Serra V, Hagemann IS, Walts AE, Karlan BY, Orsulic S, Fuh K, Sun L, Verma P, Lomonosova E, Zhao P, Khabele D, Mullen MM

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.

The Journal of clinical investigation

Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AA, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence.

The Journal of clinical investigation

Liegeois MA, Hsieh A, Al-Fouadi M, Charbit AR, Yang CX, Hackett TL, Fahy JV

Skin microbiome and dermatologic disorders.

The Journal of clinical investigation

Scharschmidt TC, Segre JA

Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.

The Journal of clinical investigation

Kumar R, Nolan K, Kassa B, Chanana N, Palmo T, Sharma K, Singh K, Mickael C, Fonseca Balladares D, Nilsson J, Prabhakar A, Mishra A, Lee MH, Sanders L, Kumar S, Molofsky AB, Stenmark KR, Sheppard D, Tuder RM, Gupta MD, Thinlas T, Pasha Q, Graham BB

Serum cAMP levels are increased in patients with asthma.

The Journal of clinical investigation

An SS, Cao G, Ahn K, Lee J, Jung DY, Denlinger L, Fahy J, Israel E, Moore W, Phillips B, Mauger D, Wenzel S, Panettieri RA

Disrupted callosal connectivity underlies long-lasting sensory-motor deficits in an NMDAreceptor antibody encephalitis mouse model.

The Journal of clinical investigation

Zhou J, Greenfield AL, Loudermilk RP, Bartley CM, Chen C, Chen X, Leroux MA, Lu Y, Necula D, Ngo TT, Tran BT, Honma PS, Lauderdale K, Zhao C, Zhou X, Wang H, Nicoll RA, Wang C, Paz JT, Palop JJ, Wilson MR, Pleasure SJ

Long COVID is associated with lower percentages of mature, cytotoxic NK cell phenotypes.

The Journal of clinical investigation

Tsao T, Buck AM, Grimbert L, LaFranchi BH, Altamirano Poblano B, Fehrman EA, Dalhuisen T, Hsue PY, Kelly JD, Martin JN, Deeks SG, Hunt PW, Peluso MJ, Aguilar OA, Henrich TJ

Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.

The Journal of clinical investigation

McCarthy EE, Yu S, Perlmutter N, Nakao Y, Naito R, Lin C, Riekher V, DeRisi J, Ye CJ, Weiss A, Ashouri JF

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