The Journal of clinical investigation

Opportunities and challenges in using real-world data for health care.

The Journal of clinical investigation

Rudrapatna VA, Butte AJ

Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.

The Journal of clinical investigation

Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR

GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.

The Journal of clinical investigation

Cheng J, Klei LR, Hubel NE, Zhang M, Schairer R, Maurer LM, Klei HB, Kang H, Concel VJ, Delekta PC, Dang EV, Mintz MA, Baens M, Cyster JG, Parameswaran N, Thome M, Lucas PC, McAllister-Lucas LM

The 2019 Nobel Prize honors fundamental discoveries in hypoxia response.

The Journal of clinical investigation

Moslehi J, Rathmell WK

The mir181ab1 cluster promotes kras-driven oncogenesis and progression in lung and pancreas.

The Journal of clinical investigation

Valencia K, Erice O, Kostyrko K, Hausmann S, Guruceaga E, Thathireddy A, Flores NM, Sayles LC, Lee AG, Fragoso R, Sun TQ, Vallejo A, Roman M, Entrialgo-Cadierno R, Migueliz I, Razquin N, Fortes P, Lecanda F, Lu J, Ponz-Sarvise M, Chen CZ, Mazur PK, Sweet-Cordero EA, Vicent S

Cellular heterogeneity in brown adipose tissue.

The Journal of clinical investigation

Oguri Y, Kajimura S

Glucocorticoids paradoxically facilitate steroid resistance in T-cell acute lymphoblastic leukemias and thymocytes.

The Journal of clinical investigation

Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.

The Journal of clinical investigation

Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice.

The Journal of clinical investigation

Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE

Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

The Journal of clinical investigation

Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson M, Oakes SA

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