The Journal of clinical investigation

Glucocorticoids paradoxically facilitate steroid resistance in T-cell acute lymphoblastic leukemias and thymocytes.

The Journal of clinical investigation

Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.

The Journal of clinical investigation

Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice.

The Journal of clinical investigation

Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE

Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

The Journal of clinical investigation

Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson M, Oakes SA

CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs.

The Journal of clinical investigation

Okimoto RA, Wu W, Nanjo S, Olivas V, Lin YK, Ponce RK, Oyama R, Kondo T, Bivona TG

mTORC1 to AMPK switching underlies ß-cell metabolic plasticity during maturation and diabetes.

The Journal of clinical investigation

Jaafar R, Tran S, Shah A, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A

CD161 contributes to prenatal immune suppression of IFN?-producing PLZF+ T cells.

The Journal of clinical investigation

Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.

The Journal of clinical investigation

LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y

Singling out Th2 cells in eosinophilic esophagitis.

The Journal of clinical investigation

Eckalbar WL, Erle DJ

Misactivation of Hedgehog signaling causes inherited and sporadic cancers.

The Journal of clinical investigation

Raleigh DR, Reiter JF

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