The Journal of clinical investigation

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.

The Journal of clinical investigation

Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y, Le D, Spina S, Grinberg LT, Seeley WW, Kramer JH, Sacktor TC, Schilling B, Gan L, Casaletto KB, Tracy TE

Keeping translational research grounded in human biology.

The Journal of clinical investigation

Haldar SM

Multi-omic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations.

The Journal of clinical investigation

Garcia JH, Akins EA, Jain S, Wolf KJ, Zhang J, Choudhary N, Lad M, Shukla P, Rios J, Seo K, Gill SA, Carson WH, Carrete LR, Zheng AC, Raleigh DR, Kumar S, Aghi MK

Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.

The Journal of clinical investigation

de Souza Goncalves L, Chu QT, Master R, Chhetri PD, Gao Q, Cil O

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.

The Journal of clinical investigation

Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P

Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors.

The Journal of clinical investigation

Sun L, Kienzler JC, Reynoso JG, Lee A, Shiuan E, Li S, Kim J, Ding L, Monteleone AJ, Owens GC, Phillips JJ, Everson RG, Nathanson D, Cloughesy TF, Li G, Liau LM, Hugo W, Kim W, Prins RM

Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.

The Journal of clinical investigation

Reyes EA, Castillo-Azofeifa D, Rispal J, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD

The SWI/SNF chromatin remodeling subunit DPF2 facilitates NRF2-dependent anti-inflammatory and anti-oxidant gene expression.

The Journal of clinical investigation

Mas G, Man N, Nakata Y, Martinez-Caja C, Karl DL, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Morey L, Bilbao D, Nimer SD

Postoperative risk of IDH mutant glioma-associated seizures and their potential management with IDH mutant inhibitors.

The Journal of clinical investigation

Drumm M, Wang W, Sears TK, Bell-Burdett K, Javier R, Cotton KY, Webb BT, Byrne KT, Unruh D, Thirunavu V, Walshon J, Steffens A, McCortney K, Lukas RV, Phillips JJ, Mohamed E, Finan JD, Santana-Santos L, Heimberger AB, Franz CK, Kurz JE, Templer JW, Swanson GT, Horbinski C

Lysosomal lipid peroxidation mediates immunogenic cell death.

The Journal of clinical investigation

Phadatare P, Debnath J

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