The Wilder lab aims to prevent immune-mediated adverse side effects associated with cytokine therapy by understanding innate immune regulation and developing dynamically controlled therapies.
In our lab, we use live imaging in the cochlea to visualize how calcium dysregulation and stress pathways cause hearing loss, to help us identify molecular targets for treatment.
We study signaling between neural tissues and bodily fluids, with a focus on specialized interfaces near brain ventricles to uncover their roles in health, disease, and therapeutic applications.
The Shy Lab employs cutting-edge genome and epigenome engineering techniques to address the current limitations in cell therapy development, manufacture, and delivery.
