Associate Professor
Primary Thematic Area
M_ObGyn-GynOnc-Core
Secondary Thematic Area
Research Summary
Developing targeted treatments in ovarian and endometrial cancer by incorporating the tumor microenvironment.
Mentorship Development
5/2024 - When Someone Isn't Meeting Your Expectations
We utilize patient-derived and mouse models to study treatment resistance and metastasis. We also utilize clinical trial specimens to perform translational research to better understand response to new therapies.
Websites
Publications
DDR2 confers ferroptosis resistance to cancer-associated fibroblasts and attenuates PARPi sensitivity of ovarian tumor cells.
Molecular cancer research : MCR
Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms.
bioRxiv : the preprint server for biology
Complete response of somatic POLE-ultramutated recurrent undifferentiated uterine sarcoma to pembrolizumab and concurrent radiotherapy.
Gynecologic oncology reports
Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.
Nature communications
Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.
The Journal of clinical investigation
New opportunities for opportunistic salpingectomy: Leveraging non-gynecologic surgeries for ovarian cancer prevention.
Gynecologic oncology reports
APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition.
JCI insight
Fragmented Care and Guideline-Concordant Treatment in Locally Advanced Cervical Cancer.
Obstetrics and gynecology
Delay to timely treatment in locally advanced cervical cancer - insurance inequities in access to gynecologic oncology.
American journal of obstetrics and gynecology
Replication stress marker phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.
bioRxiv : the preprint server for biology
Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice.
Nanomaterials (Basel, Switzerland)
APOBEC3A drives metastasis of high-grade serous ovarian cancer by altering epithelial-to-mesenchymal transition.
bioRxiv : the preprint server for biology
A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells.
Nucleic acids research
A toolkit for a modern gynecologic oncology tissue bank.
Gynecologic oncology
Updates in the Use of Targeted Therapies for Gynecologic Cancers.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Endometrial cancer at recurrence: To re-sequence or not to re-sequence.
Gynecologic oncology reports
ROR2/Wnt5a Signaling Regulates Directional Cell Migration and Early Tumor Cell Invasion in Ovarian Cancer.
Molecular cancer research : MCR
Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Extracellular Matrix Proteins.
Molecular cancer research : MCR
Genetic characterization of primary and metastatic high-grade serous ovarian cancer tumors reveals distinct features associated with survival.
Communications biology
Reproductive Scientist Development Program: Bridging the Gap to the Physician Scientist Career.
Reproductive sciences (Thousand Oaks, Calif.)
Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays.
Journal of visualized experiments : JoVE
Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids.
Journal of visualized experiments : JoVE
Identity-related experiences of Asian American trainees in gynecologic oncology.
Gynecologic oncology reports
Community access to primary care is an important geographic disparity among ovarian cancer patients undergoing cytoreductive surgery.
Gynecologic oncology reports
State of the Biomarker Science in Ovarian Cancer: A National Cancer Institute Clinical Trials Planning Meeting Report.
JCO precision oncology
High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer.
Gynecologic oncology
Gynecologic oncology patient perspectives and knowledge on advance care planning: A quality improvement intervention.
Gynecologic oncology reports
GAS6-AXL Inhibition by AVB-500 Overcomes Resistance to Paclitaxel in Endometrial Cancer by Decreasing Tumor Cell Glycolysis.
Molecular cancer therapeutics
Ridiculously good writing: How to write like a pro and publish like a boss.
Gynecologic oncology reports
Mismatch repair deficiency in ovarian cancer.
Gynecologic oncology reports
Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment.
Nature communications
Impact of the COVID-19 pandemic on referral to and delivery of gynecologic oncology care.
Gynecologic oncology reports
Culturing Primary Human Mesothelial Cells.
Methods in molecular biology (Clifton, N.J.)
GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress.
Molecular cancer research : MCR
Phase 1b study of AVB-500 in combination with paclitaxel or pegylated liposomal doxorubicin platinum-resistant recurrent ovarian cancer.
Gynecologic oncology
Phase I Trial of Stereotactic MRI-Guided Online Adaptive Radiation Therapy (SMART) for the Treatment of Oligometastatic Ovarian Cancer.
International journal of radiation oncology, biology, physics
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.
Nature communications
Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling.
The Journal of clinical investigation
Text-message-based behavioral weight loss for endometrial cancer survivors with obesity: A randomized controlled trial.
Gynecologic oncology
Radiation therapy for vaginal and perirectal lesions in recurrent ovarian cancer.
Gynecologic oncology reports
Entinostat, a selective HDAC1/2 inhibitor, potentiates the effects of olaparib in homologous recombination proficient ovarian cancer.
Gynecologic oncology
A deficit-accumulation frailty index predicts survival outcomes in patients with gynecologic malignancy.
Gynecologic oncology
Obese endometrial cancer survivors' perceptions of weight loss strategies and characteristics that may influence participation in behavioral interventions.
Gynecologic oncology reports
Impact of employment and insurance status on distress in gynecologic oncology patients.
Gynecologic oncology
The role of endometrial sampling for surveillance of recurrence in postmenopausal patients with medically inoperable stage I endometrial cancer.
Gynecologic oncology reports
Clinical assays for assessment of homologous recombination DNA repair deficiency.
Gynecologic oncology
Homologous recombination deficiency real-time clinical assays, ready or not?
Gynecologic oncology
Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT).
Gynecologic oncology reports
A fellow-run clinic achieves similar patient outcomes as faculty clinics: A safe and feasible model for gynecologic oncology fellow education.
Gynecologic oncology
FIGO 2018 staging criteria for cervical cancer: Impact on stage migration and survival.
Gynecologic oncology
Low rates of cascade genetic testing among families with hereditary gynecologic cancer: An opportunity to improve cancer prevention.
Gynecologic oncology
S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma.
Cancer research
Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients.
Gynecologic oncology
Type II endometrial cancers with minimal, non-invasive residual disease on final pathology: What should we do next?
Gynecologic oncology reports
Do gynecologic oncology patients with severely diminished renal function and urinary tract obstruction benefit from ureteral stenting or percutaneous nephrostomy?
Gynecologic oncology reports
p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts.
Scientific reports
Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.
Cancer research
Inpatient management of hypercalcemia portends a poor prognosis among gynecologic oncology patients: A trigger to initiate hospice care?
Gynecologic oncology reports
Association between body mass index and surgical menopausal symptoms in patients with early stage endometrial cancer.
Gynecologic oncology
Untitled Publication
Gynecologic oncology reports
Therapeutic Inhibition of the Receptor Tyrosine Kinase AXL Improves Sensitivity to Platinum and Taxane in Ovarian Cancer.
Molecular cancer therapeutics
SQ1274, a novel microtubule inhibitor, inhibits ovarian and uterine cancer cell growth.
Gynecologic oncology
Gynecologic Oncologists' Perceptions of Palliative Care and Associated Barriers: A Survey of the Society of Gynecologic Oncology.
Gynecologic and obstetric investigation
TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis.
Oncogene
Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer.
Molecular cancer therapeutics
Radiation Therapy for Recurrent Clear-Cell Cancer of the Ovary.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
The association between timing of initiation of adjuvant therapy and the survival of early stage ovarian cancer patients - An analysis of NRG Oncology/Gynecologic Oncology Group trials.
Gynecologic oncology
Summary of the 2016 American Association for Cancer Research (AACR) Annual Meeting.
Gynecologic oncology
Comparison of bevacizumab alone or with chemotherapy in recurrent ovarian cancer patients.
Gynecologic oncology
Survival differences of Asian and Caucasian epithelial ovarian cancer patients in the United States.
Gynecologic oncology
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.
Proceedings of the National Academy of Sciences of the United States of America
Concomitant chemotherapy and radiation for the treatment of advanced-stage endometrial cancer.
Gynecologic oncology
Utilization of and charges for robotic versus laparoscopic versus open surgery for endometrial cancer.
Journal of surgical oncology
Current management of vulvar cancer.
Hematology/oncology clinics of North America
Oral misoprostol and vaginal isosorbide mononitrate for labor induction: a randomized controlled trial.
Obstetrics and gynecology
Daily compared with 8-hour gentamicin for the treatment of intrapartum chorioamnionitis: a randomized controlled trial.
Obstetrics and gynecology
The treatment and outcomes of early-stage epithelial ovarian cancer: have we made any progress?
British journal of cancer
Mesenteric hemodynamic response to circulatory shock.
Current opinion in critical care
Signal transduction by reactive oxygen species: alternative paradigms for signaling specificity.
Surgery
The mesenteric hemodynamic response to circulatory shock: an overview.
Shock (Augusta, Ga.)
Hemodynamic pathogenesis of ischemic hepatic injury following cardiogenic shock/resuscitation.
Shock (Augusta, Ga.)
Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release.
American journal of physiology. Heart and circulatory physiology
Mesenteric vasoconstriction in response to hemorrhagic shock.
Shock (Augusta, Ga.)