affiliate

We develop new approaches to decipher communication between the brain and immune system. We study what these messages mean, how they’re regulated, and how they impact brain health.

The Shokat lab uses chemical genetics to study and target signaling proteins, with the aim of finding new ways to treat human diseases.

We are interested in understanding how dysfunctional hematopoiesis leads to dysfunctional immune cells which can modulate cardiovascular disease.

Therapeutics and Functional Genomics in Hematologic Cancers

The Watkins Lab studies axonal stress signaling to understand how transcriptional programs determine neuronal fate in injury and disease, from driving neurodegeneration to enabling axon regeneration

NK cells, NK receptors, and NK ligands in viral immunity and tumor immunity.

We study the origins of clonal blood disorders with focus on developmental hematopoiesis and forces driving clonal competition in the context of inherited cancer predisposition conditions.

We use synthetic biology and high-throughput functional genetic screens to understand antigen presentation and T-cell recognition in the context of cancer and other diseases.

Mechanisms of Macrophage-Mediated Cell Clearance

Mechanisms underlying transcriptional dysregulation, DNA damage responses, inflammation and resistance. Design theranostics targeting the cancer surface proteome and define synthetic lethal interactions.