
Professor in Residence
Primary Thematic Area
M_Neurology
Secondary Thematic Area
Research Summary
My research specialism is the brain and therapeutic action of psychedelic drugs.
Publications
Reduced Brain Responsiveness to Emotional Stimuli With Escitalopram But Not Psilocybin Therapy for Depression.
The American journal of psychiatry
Dissociable effects of psilocybin and escitalopram for depression on processing of musical surprises.
Molecular psychiatry
Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness.
Neuroscience of consciousness
Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience.
Communications biology
Decreased CO2 saturation during circular breathwork supports emergence of altered states of consciousness.
Communications psychology
Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models.
Neuroscience and biobehavioral reviews
The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State.
Human brain mapping
Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).
Communications biology
Psilocybin for disorders of consciousness: A case-report study.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
A Field-Wide Review and Analysis of Study Materials Used in Psilocybin Trials: Assessment of Two Decades of Research.
Psychedelic medicine (New Rochelle, N.Y.)
On Minimizing Risk and Harm in the Use of Psychedelics.
Psychiatric research and clinical practice
A qualitative analysis of the psychedelic mushroom come-up and come-down.
Npj mental health research
From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS).
Scientific reports
The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression.
Journal of affective disorders
Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.
Translational psychiatry
Examining differences in the effects and contexts of naturalistic psilocybin use for White participants vs. participants of Color: A longitudinal online survey study.
Journal of affective disorders
Validation of the imperial psychedelic predictor scale.
Psychological medicine
Reply to Letter to the Editor: "Psychedelics in Older Adults: Difficulties of a Clear Therapeutic Evidence".
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being.
Journal of psychopharmacology (Oxford, England)
Within-subject comparison of near-death and psychedelic experiences: acute and enduring effects.
Neuroscience of consciousness
Can Psychedelic Use Benefit Meditation Practice? Examining Individual, Psychedelic, and Meditation-Related Factors.
medRxiv : the preprint server for health sciences
Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience.
bioRxiv : the preprint server for biology
Psychotomimetic compensation versus sensitization.
Pharmacology research & perspectives
A synergistic workspace for human consciousness revealed by Integrated Information Decomposition.
eLife
Longitudinal experiences of Canadians receiving compassionate access to psilocybin-assisted psychotherapy.
Scientific reports
Interrupting the Psychedelic Experience Through Contextual Manipulation to Study Experience Efficacy.
JAMA Network Open
Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?
Frontiers in human neuroscience
Psychological effects of psychedelics in adolescents.
Frontiers in child and adolescent psychiatry
Study protocol for "Psilocybin in patients with fibromyalgia: brain biomarkers of action".
Frontiers in psychiatry
Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT.
bioRxiv : the preprint server for biology
Effects of Psychedelics in Older Adults: A Prospective Cohort Study.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Psychedelics and the 'inner healer': Myth or mechanism?
Journal of psychopharmacology (Oxford, England)
Long-term benefits to psychological health and well-being after ceremonial use of Ayahuasca in Middle Eastern and North African immigrants and refugees.
Frontiers in psychiatry
The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework.
National science review
Effects of discontinuation of serotonergic antidepressants prior to psilocybin therapy versus escitalopram for major depression.
Journal of psychopharmacology (Oxford, England)
Psychiatric risks for worsened mental health after psychedelic use.
Journal of psychopharmacology (Oxford, England)
The Relationship Between Changes in Mindfulness and Subsequent Changes in Well-Being Following Psychedelic Use: Prospective Cohort Study.
JMIR formative research
Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity.
Journal of affective disorders
Brain dynamics predictive of response to psilocybin for treatment-resistant depression.
Brain Communications
Effects of DMT on mental health outcomes in healthy volunteers.
Scientific reports
Psychedelics and sexual functioning: a mixed-methods study.
Scientific reports
Development of the Japanese version of the Ego-Dissolution Inventory (EDI).
Neuropsychopharmacology reports
Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study.
Journal of psychopharmacology (Oxford, England)
Assessing expectancy and suggestibility in a trial of escitalopram v. psilocybin for depression.
Psychological medicine
Effects of External Stimulation on Psychedelic State Neurodynamics.
ACS chemical neuroscience
A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex.
Brain : a journal of neurology
Psilocybin and Other Classic Psychedelics in Depression.
Current topics in behavioral neurosciences
5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?
Psychopharmacology
Psychological and physiological effects of extended DMT.
Journal of psychopharmacology (Oxford, England)
Case analysis of long-term negative psychological responses to psychedelics.
Scientific reports
Optimized infusion rates for N,N-dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework.
CPT: pharmacometrics & systems pharmacology
Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences.
Scientific reports
Psilocybin therapy for treatment resistant depression: prediction of clinical outcome by natural language processing.
Psychopharmacology
The difference between 'placebo group' and 'placebo control': a case study in psychedelic microdosing.
Scientific reports
Assessing the risk of symptom worsening in psilocybin-assisted therapy for depression: A systematic review and individual participant data meta-analysis.
Psychiatry research
Personality Change in a Trial of Psilocybin Therapy vs Escitalopram Treatment for Depression - CORRIGENDUM.
Psychological medicine
Pattern breaking: a complex systems approach to psychedelic medicine.
Neuroscience of consciousness
In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape.
Science advances
Personality change in a trial of psilocybin therapy v. escitalopram treatment for depression.
Psychological medicine
Emerging Challenges for Psychedelic Therapy.
JAMA psychiatry
Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience.
bioRxiv : the preprint server for biology
How does psilocybin therapy work? An exploration of experiential avoidance as a putative mechanism of change.
Journal of affective disorders
A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression.
Journal of psychopharmacology (Oxford, England)
Increased low-frequency brain responses to music after psilocybin therapy for depression.
Journal of affective disorders
A whole-brain model of the neural entropy increase elicited by psychedelic drugs.
Scientific reports
Spatial Correspondence of LSD-Induced Variations on Brain Functioning at Rest With Serotonin Receptor Expression.
Biological psychiatry. Cognitive neuroscience and neuroimaging
Editorial: Frontiers in psychodynamic neuroscience.
Frontiers in human neuroscience
Human brain effects of DMT assessed via EEG-fMRI.
Proceedings of the National Academy of Sciences of the United States of America
N,N-dimethyltryptamine affects electroencephalography response in a concentration-dependent manner-A pharmacokinetic/pharmacodynamic analysis.
CPT: pharmacometrics & systems pharmacology
A complex systems perspective on psychedelic brain action.
Trends in cognitive sciences
LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics.
PLoS computational biology
Translational Challenges in Psychedelic Medicine.
The New England journal of medicine
Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.
Communications biology
Among psychedelic-experienced users, only past use of psilocybin reliably predicts nature relatedness.
Journal of psychopharmacology (Oxford, England)
Canalization and plasticity in psychopathology.
Neuropharmacology
Oxygen and the Spark of Human Brain Evolution: Complex Interactions of Metabolism and Cortical Expansion across Development and Evolution.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Changes in music-evoked emotion and ventral striatal functional connectivity after psilocybin therapy for depression.
Journal of psychopharmacology (Oxford, England)
Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans.
Psychological medicine
Body mass index (BMI) does not predict responses to psilocybin.
Journal of psychopharmacology (Oxford, England)
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression.
The New England journal of medicine
A Bayesian Reanalysis of a Trial of Psilocybin versus Escitalopram for Depression.
Psychedelic medicine (New Rochelle, N.Y.)
Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape.
Nature communications
Effects of classic psychedelic drugs on turbulent signatures in brain dynamics.
Network neuroscience (Cambridge, Mass.)
Population pharmacokinetic/pharmacodynamic modeling of the psychedelic experience induced by N,N-dimethyltryptamine - Implications for dose considerations.
Clinical and translational science
Retraction Note: A mechanistic model of the neural entropy increase elicited by psychedelic drugs.
Scientific reports
Effects of psilocybin versus escitalopram on rumination and thought suppression in depression.
BJPsych open
The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world.
Psychopharmacology
Antidepressant effects of a psychedelic experience in a large prospective naturalistic sample.
Journal of psychopharmacology (Oxford, England)
Phenomenology and content of the inhaled N, N-dimethyltryptamine (N, N-DMT) experience.
Scientific reports
Greater than the parts: a review of the information decomposition approach to causal emergence.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses.
Neuroscience and biobehavioral reviews
Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression.
Frontiers in pharmacology
Consciousness is supported by near-critical slow cortical electrodynamics.
Proceedings of the National Academy of Sciences of the United States of America
Development and application of a highly sensitive LC-MS/MS method for simultaneous quantification of N,N-dimethyltryptamine and two of its metabolites in human plasma.
Journal of pharmaceutical and biomedical analysis
Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience.
Journal of psychopharmacology (Oxford, England)
Examining Psychedelic-Induced Changes in Social Functioning and Connectedness in a Naturalistic Online Sample Using the Five-Factor Model of Personality.
Frontiers in psychology
Psychedelics alter metaphysical beliefs.
Scientific reports
What it is like to be a bit: an integrated information decomposition account of emergent mental phenomena.
Neuroscience of consciousness
Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research.
Frontiers in psychiatry
Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey.
Psychopharmacology
Study Protocol for "Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study".
Frontiers in psychiatry
Co-design of Guidance for Patient and Public Involvement in Psychedelic Research.
Frontiers in psychiatry
Prefrontal contributions to the stability and variability of thought and conscious experience.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Psilocybin for Depression. Reply.
The New England journal of medicine
Turn on, Tune in, and Drop out: Predictors of Attrition in a Prospective Observational Cohort Study on Psychedelic Use.
Journal of medical Internet research
Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?
Frontiers in psychiatry
Associations between lifetime classic psychedelic use and cardiometabolic diseases.
Scientific reports
Sustained, Multifaceted Improvements in Mental Well-Being Following Psychedelic Experiences in a Prospective Opportunity Sample.
Frontiers in psychiatry
Psychedelics and health behaviour change.
Journal of psychopharmacology (Oxford, England)
Relational Processes in Ayahuasca Groups of Palestinians and Israelis.
Frontiers in pharmacology
Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine?
Journal of psychopharmacology (Oxford, England)
Trial of Psilocybin versus Escitalopram for Depression.
The New England journal of medicine
Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness.
Frontiers in pharmacology
Association Between Lifetime Classic Psychedelic Use and Hypertension in the Past Year.
Hypertension (Dallas, Tex. : 1979)
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings.
Journal of psychopharmacology (Oxford, England)
Trends in the Top-Cited Articles on Classic Psychedelics.
Journal of psychoactive drugs
The Current Status of Psychedelics in Psychiatry.
JAMA psychiatry
Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing.
Scientific reports
Reconciling emergences: An information-theoretic approach to identify causal emergence in multivariate data.
PLoS computational biology
The entropic tongue: Disorganization of natural language under LSD.
Consciousness and cognition
The potential synergistic effects between psychedelic administration and nature contact for the improvement of mental health.
Health psychology open
Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison.
Schizophrenia bulletin
Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern-era clinical studies.
Acta psychiatrica Scandinavica
Pivotal mental states.
Journal of psychopharmacology (Oxford, England)
A mechanistic model of the neural entropy increase elicited by psychedelic drugs.
Scientific reports
Positive effects of psychedelics on depression and wellbeing scores in individuals reporting an eating disorder.
Eating and weight disorders : EWD
Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation.
Frontiers in psychiatry
Acute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment.
Journal of psychopharmacology (Oxford, England)
Dynamic coupling of whole-brain neuronal and neurotransmitter systems.
Proceedings of the National Academy of Sciences of the United States of America
Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression.
Journal of psychopharmacology (Oxford, England)
Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers.
Psychopharmacology
From Egoism to Ecoism: Psychedelics Increase Nature Relatedness in a State-Mediated and Context-Dependent Manner.
International journal of environmental research and public health
Neural correlates of the DMT experience assessed with multivariate EEG.
Scientific reports
Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory.
Journal of psychopharmacology (Oxford, England)
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics.
Pharmacological reviews
Replication and extension of a model predicting response to psilocybin.
Psychopharmacology
Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin.
NeuroImage
Psychedelics as a treatment for disorders of consciousness.
Neuroscience of consciousness
Recreational use of psychedelics is associated with elevated personality trait openness: Exploration of associations with brain serotonin markers.
Journal of psychopharmacology (Oxford, England)
How do psychedelics work?
Current opinion in psychiatry
Predicting Responses to Psychedelics: A Prospective Study.
Frontiers in pharmacology
Common neural signatures of psychedelics: Frequency-specific energy changes and repertoire expansion revealed using connectome-harmonic decomposition.
Progress in brain research
More Realistic Forecasting of Future Life Events After Psilocybin for Treatment-Resistant Depression.
Frontiers in psychology
Serotonin, psychedelics and psychiatry.
World psychiatry : official journal of the World Psychiatric Association (WPA)
Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.
Current biology : CB
Psychedelics, Meditation, and Self-Consciousness.
Frontiers in psychology
DMT Models the Near-Death Experience.
Frontiers in psychology
Effects of psilocybin therapy on personality structure.
Acta psychiatrica Scandinavica
Psilocybin and MDMA reduce costly punishment in the Ultimatum Game.
Scientific reports
Correction to: The hidden therapist: evidence for a central role of music in psychedelic therapy.
Psychopharmacology
Natural speech algorithm applied to baseline interview data can predict which patients will respond to psilocybin for treatment-resistant depression.
Journal of affective disorders
The entropic brain - revisited.
Neuropharmacology
Psychedelics and the essential importance of context.
Journal of psychopharmacology (Oxford, England)
The hidden therapist: evidence for a central role of music in psychedelic therapy.
Psychopharmacology
Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression.
Journal of psychopharmacology (Oxford, England)
Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression.
Frontiers in pharmacology
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression.
Neuropharmacology
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Scientific reports
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
Neuropharmacology
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.
Psychopharmacology
Psilocybin with psychological support improves emotional face recognition in treatment-resistant depression.
Psychopharmacology
Serotonin and brain function: a tale of two receptors.
Journal of psychopharmacology (Oxford, England)
Psychedelics and connectedness.
Psychopharmacology
Psychedelics, Personality and Political Perspectives.
Journal of psychoactive drugs
The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin.
Scientific reports
Psychedelics and the science of self-experience.
The British journal of psychiatry : the journal of mental science
Concerns regarding conclusions made about LSD-treatments (received 25 October 2016).
History of psychiatry
Altered Insula Connectivity under MDMA.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Question-based Drug Development for psilocybin - Authors' reply.
The lancet. Psychiatry
Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI).
Frontiers in human neuroscience
Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study.
The lancet. Psychiatry
LSD-induced entropic brain activity predicts subsequent personality change.
Human brain mapping
LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.
Human brain mapping
Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution.
Current biology : CB
LSD modulates music-induced imagery via changes in parahippocampal connectivity.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Neural correlates of the LSD experience revealed by multimodal neuroimaging.
Proceedings of the National Academy of Sciences of the United States of America
Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide.
Journal of psychopharmacology (Oxford, England)
The paradoxical psychological effects of lysergic acid diethylamide (LSD).
Psychological medicine
LSD enhances the emotional response to music.
Psychopharmacology
Finding the self by losing the self: Neural correlates of ego-dissolution under psilocybin.
Human brain mapping
Drug models of schizophrenia.
Therapeutic advances in psychopharmacology
Homological scaffolds of brain functional networks.
Journal of the Royal Society, Interface
LSD enhances suggestibility in healthy volunteers.
Psychopharmacology
Enhanced repertoire of brain dynamical states during the psychedelic experience.
Human brain mapping
The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers.
Frontiers in human neuroscience
Was it a vision or a waking dream?
Frontiers in psychology
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs.
Frontiers in human neuroscience
A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment.
Current drug abuse reviews
The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories.
The international journal of neuropsychopharmacology
Broadband cortical desynchronization underlies the human psychedelic state.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Experienced drug users assess the relative harms and benefits of drugs: a web-based survey.
Journal of psychoactive drugs
Psychiatry's next top model: cause for a re-think on drug models of psychosis and other psychiatric disorders.
Journal of psychopharmacology (Oxford, England)
Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis.
Schizophrenia bulletin
Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin.
The British journal of psychiatry : the journal of mental science
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin.
Proceedings of the National Academy of Sciences of the United States of America
A web-based survey on mephedrone.
Drug and alcohol dependence
The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability.
Journal of psychopharmacology (Oxford, England)
The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas.
Brain : a journal of neurology
Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls.
Psychopharmacology
Mourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry.
Annals of general psychiatry
Current and former ecstasy users report different sleep to matched controls: a web-based questionnaire study.
Journal of psychopharmacology (Oxford, England)