Kevan Shokat, PhD

Professor

Cellular Molecular Pharmacology

[email protected]

+1 415 514-0472

Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Neurobiology

Research Summary:

The Shokat lab uses chemical genetics to study and target signaling proteins, with the aim of finding new ways to treat human diseases.

Publications:

Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.

Nature chemical biology

Zheng Q, Zhang Z, Guiley KZ, Shokat KM

Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.

Analytical chemistry

Malakoutikhah M, Mahran R, Gooran N, Masoumi A, Lundell K, Liljeblad A, Guiley K, Dai S, Zheng Q, Zhu L, Shokat KM, Kopra K, Härmä H

Selective activation of intracellular β1AR using a spatially restricted antagonist.

bioRxiv : the preprint server for biology

Liccardo F, Morstein J, Lin TY, Pampel J, Shokat KM, Irannejad R

Protocol for performing and optimizing differential scanning fluorimetry experiments.

STAR protocols

Wu T, Hornsby M, Zhu L, Yu JC, Shokat KM, Gestwicki JE

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.

Nature communications

Haas KM, McGregor MJ, Bouhaddou M, Polacco BJ, Kim EY, Nguyen TT, Newton BW, Urbanowski M, Kim H, Williams MAP, Rezelj VV, Hardy A, Fossati A, Stevenson EJ, Sukerman E, Kim T, Penugonda S, Moreno E, Braberg H, Zhou Y, Metreveli G, Harjai B, Tummino TA, Melnyk JE, Soucheray M, Batra J, Pache L, Martin-Sancho L, Carlson-Stevermer J, Jureka AS, Basler CF, Shokat KM, Shoichet BK, Shriver LP, Johnson JR, Shaw ML, Chanda SK, Roden DM, Carter TC, Kottyan LC, Chisholm RL, Pacheco JA, Smith ME, Schrodi SJ, Albrecht RA, Vignuzzi M, Zuliani-Alvarez L, Swaney DL, Eckhardt M, Wolinsky SM, White KM, Hultquist JF, Kaake RM, García-Sastre A, Krogan NJ