Kevan Shokat, PhD

Professor

Cellular Molecular Pharmacology

[email protected]

+1 415 514-0472

Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Neurobiology

Research Summary:

The Shokat lab uses chemical genetics to study and target signaling proteins, with the aim of finding new ways to treat human diseases.

Publications:

IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.

Proceedings of the National Academy of Sciences of the United States of America

Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.

Leukemia

Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP

Direct RAS inhibitors turn 10.

Nature chemical biology

Ostrem JML, Peters U, Shokat KM

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity.

bioRxiv : the preprint server for biology

Le Belle JE, Condro M, Cepeda C, Oikonomou KD, Tessema K, Dudley L, Schoenfield J, Kawaguchi R, Geschwind D, Silva AJ, Zhang Z, Shokat K, Harris NG, Kornblum HI

IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.