Warner Greene, MD, PhD

Nick and Sue Hellman Distinguished Professor of Translational Medicine
Director and Senior Investigator, Gladstone Institute of Virology and Immunology
Co-Director, UCSF-GIVI Center for AIDS Research
Professor
Department of Medicine
Department of Microbiology and Immunology
+1 415 734-4805
Research Description: 

Warner C. Greene, MD, PhD is Director of the Gladstone Center for HIV Cure Research, Senior Investigator, and Nick and Sue Hellmann Distinguished Professor of Translational Medicine at the Gladstone Institute of Virology and Immunology (GIVI). He is the Founding and Emeritus Director of GIVI. Dr. Greene is also Professor of Medicine, Microbiology and of Immunology at UCSF. Dr. Greene is a member of the Institute of Medicine of the National Academies and a fellow of the American Academy for the Advancement of Science. He also serves as Co-Director of the UCSF-Gladstone Center for AIDS Research, and has served as a Councilor and President of the Association of American Physicians. Dr. Greene earned a bachelor’s degree at Stanford University and an MD/PhD at Washington University School of Medicine. He took his internship and residency training in Medicine at the Massachusetts General Hospital at Harvard. After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991. The ongoing research in Dr. Greene’s laboratory focuses on the molecular mechanisms underlying HIV pathogenesis, latency, and transmission. He is the author of more than 380 scientific papers and has been recognized as one of the 100 Most Cited Scientists in the world. In 2007, Dr. Greene expanded his work to include global health in sub-Saharan Africa in his service as president and executive chairman of the Accordia Global Health Foundation. Accordia established the Infectious Diseases Institute at Makerere University in Uganda, which has trained thousands of African health care workers, is caring for 30,000 HIV-infected patients, and has brought health care to nearly 500,000 people living in remote rural regions of Uganda. In 2016, Accordia merged with Africare.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Molecular Analysis of HIV Pathogenesis

Websites

Publications: 

HIV-2 depletes CD4 T cells through pyroptosis despite Vpx-dependent degradation of SAMHD1.

Journal of virology

Luo X, Herzig E, Doitsh G, Grimmett ZW, Muñoz-Arias I, Greene WC

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency.

Retrovirology

Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform.

Cell

Herzig E, Kim KC, Packard TA, Vardi N, Schwarzer R, Gramatica A, Deeks SG, Williams SR, Landgraf K, Killeen N, Martin DW, Weinberger LS, Greene WC

Tissue microenvironment initiates an immune response to structural components of S. aureus.

Experimental dermatology

Mainzer C, Packard T, Bordes S, Closs B, Greene WC, Elias PM, Uchida Y

Distinct mechanisms regulate IL1B gene transcription in lymphoid CD4 T cells and monocytes.

Cytokine

Pulugulla SH, Packard TA, Galloway NLK, Grimmett ZW, Doitsh G, Adamik J, Galson DL, Greene WC, Auron PE