Nadav Ahituv, PhD

Department of Bioengineering and Therapeutic Sciences
+1 415 476-1838
Research Description: 

The Ahituv lab is focused on understanding the role of regulatory sequences in human biology and disease. Through a combination of comparative genomic strategies, biochemical assays, regulatory element analysis, human patient samples, mouse and fish genetic engineering technologies, and massively parallel reporter assays they are working to elucidate mechanisms whereby genetic variation within these sequences lead to changes in human phenotypes.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Gene regulation and human disease



Asymmetron: a toolkit for the identification of strand asymmetry patterns in biological sequences.

Nucleic acids research

Georgakopoulos-Soares I, Mouratidis I, Parada GE, Matharu N, Hemberg M, Ahituv N

Genomic characterization of the adolescent idiopathic scoliosis associated transcriptome and regulome.

Human molecular genetics

Makki N, Zhao J, Liu Z, Eckalbar WL, Ushiki A, Khanshour AM, Wu J, Rios J, Gray RS, Wise CA, Ahituv N

Author Correction: lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.

Nature protocols

Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulos-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N

A systematic evaluation of the design and context dependencies of massively parallel reporter assays.

Nature methods

Klein JC, Agarwal V, Inoue F, Keith A, Martin B, Kircher M, Ahituv N, Shendure J

Modulating gene regulation to treat genetic disorders.

Nature reviews. Drug discovery

Matharu N, Ahituv N