Nadav Ahituv, PhD

Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 476-1838
Research Description: 

The Ahituv lab is focused on identifying gene regulatory elements and linking nucleotide variation within them to various phenotypes including morphological differences between species, drug response and human disease. It develops and uses massively parallel reporter assays (MPRAs) that allow for high-throughput functional characterization of gene regulatory elements. In addition, the lab pioneered cis-regulation therapy (CRT), the use of gene regulatory elements as therapeutic targets for haploinsufficient disorders, and adipose modulation transplantation (AMT), a novel cancer cell therapy.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Gene regulation and human disease
Mentorship Development: 

4/2019 - Acknowledging and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab
4/2019 - Sharpening your Mentoring Skills (SyMS) with Sharon Milgram
6/2020 - Your Role in Workplace Diversity
10/2020 - DEI Champion Training
2/2021 - Three Truths & Three Tries: Facing & Overcoming Critical Social Justice Challenges at the Micro, Mezzo & Macro Levels
10/2021 - Sharpening Your Research Mentoring Skills
5/5/2022 - PSPG Faculty Community Circle
12/2022 - Faculty Development Training: Faculty as People Managers
10-11/2023 - UCSF Inclusive Mentor/Manager Training

Websites

Publications: 

Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity.

Nature communications

Kosicki M, Laboy Cintrón D, Keukeleire P, Schubach M, Page NF, Georgakopoulos-Soares I, Akiyama JA, Plajzer-Frick I, Novak CS, Kato M, Hunter RD, von Maydell K, Barton S, Godfrey P, Beckman E, Sanders SJ, Kircher M, Pennacchio LA, Ahituv N

Massively parallel jumping assay decodes Alu retrotransposition activity.

Nature communications

Matharu N, Zhao J, Sohota A, Deng L, Hung Y, Li Z, An K, Sims J, Rattanasopha S, Meyer TJ, Carbone L, Kircher M, Ahituv N

Functional characterization of OXTR-associated enhancers.

Human molecular genetics

Laboy Cintrón D, Sheng RR, Ahituv N

MPRAbase a Massively Parallel Reporter Assay database.

Genome research

Zhao J, Baltoumas FA, Konnaris MA, Mouratidis I, Liu Z, Sims J, Agarwal V, Pavlopoulos GA, Georgakopoulos-Soares I, Ahituv N

Deletion of an evolutionarily conserved TAD boundary impacts spermatogenesis in mice†.

Biology of reproduction

Lima AC, Okhovat M, Stendahl AM, Yang R, VanCampen J, Nevonen KA, Herrera J, Li W, Harshman L, Fedorov LM, Vigh-Conrad KA, Ahituv N, Conrad DF, Carbone L