Nadav Ahituv, PhD

Professor

Department of Bioengineering and Therapeutic Sciences

+1 415 476-1838

Research Description:

The Ahituv lab is focused on understanding the role of regulatory sequences in human biology and disease. Through a combination of comparative genomic strategies, biochemical assays, regulatory element analysis, human patient samples, mouse and fish genetic engineering technologies, and massively parallel reporter assays they are working to elucidate mechanisms whereby genetic variation within these sequences lead to changes in human phenotypes.

Primary Thematic Area:

Human Genetics

Secondary Thematic Area:

Developmental & Stem Cell Biology

Research Summary:

Gene regulation and human disease

Websites

Publications:

Author Correction: lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.

Nature protocols

Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulos-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N

A systematic evaluation of the design and context dependencies of massively parallel reporter assays.

Nature methods

Klein JC, Agarwal V, Inoue F, Keith A, Martin B, Kircher M, Ahituv N, Shendure J

Modulating gene regulation to treat genetic disorders.

Nature reviews. Drug discovery

Matharu N, Ahituv N

Co-option of the lineage-specific LAVA retrotransposon in the gibbon genome.

Proceedings of the National Academy of Sciences of the United States of America

Okhovat M, Nevonen KA, Davis BA, Michener P, Ward S, Milhaven M, Harshman L, Sohota A, Fernandes JD, Salama SR, O'Neill RJ, Ahituv N, Veeramah KR, Carbone L

lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.