Clinical translational research to identify host genetic and immunologic predictors of infectious diseases (e.g., HIV and SARS-CoV-2) using high dimensional single cell and systems biology approaches.
Large-scale analysis of disease genomes by integrating multi-omics data, evolutionary insights, health records, and digitized clinical traits from imaging and wearable sensor readouts.
Basic and translational research of treatment resistance in cancers of the nervous system using high throughput functional genomics and epigenetic engineering approaches.
The Locksley lab is studying the foundations of allergic immunity and attempting to define the underlying processes mediated by this type of host response