Takashi Mikawa, PhD

Cardiovascular Research Institute
+1 415 476-3230
Research Overview: 

Multi-cellular organ systems develop through non-steady state reactions that orchestrate the differentiation and integration of many cell types. Using the cardiovascular and central nervous systems as model organs, our group investigates specific reactions that define cell fate decision, cell size and shape, body axis formation, and faithful delivery of parental genomes to all daughter cells during organ formation. These include mechanisms responsible for: a) establishment of the midline identity along which the tubular organ primordium forms; b) subdivision of neural and non-neural zones within the retina, and segregation of pacemaker from ordinary heart muscle zones within cardiogenic mesoderm; c) diversification within clone units of the brain and heart into glial or neuronal cell fates (brain) or myocytes vs. impulse conducting cell linages (heart); d) formation, recruitment, and in situ patterning of an extra-cardiac progenitor population which establishes the coronary vascular network of the heart; and e) positioning of paternal and maternal chromosome during cell division.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Vascular & Cardiac Biology
Research Summary: 
Developmental Regulation of Organogenesis
Mentorship Development: 

4/26/19    Sharpening your Mentoring Skills (SyMS) with Sharon Milgram (Mission Bay)
2/18/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels



Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.

bioRxiv : the preprint server for biology

Asai R, Prakash VN, Sinha S, Prakash M, Mikawa T

Population Analysis of Daptomycin-non-Susceptible Methicillin-Resistant Staphylococcus aureus Reveals the Presence of Variants That Contribute to Daptomycin Resistance.

Current microbiology

Kanesaka I, Yabuta J, Jitsukawa T, Fujisaki S, Morita M, Mikawa T, Kanayama Katsuse A, Takahashi H, Ohno A, Kobayashi I

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.

bioRxiv : the preprint server for biology

Cai P, Casas CJ, Hua LL, Mikawa T

Mitotic Antipairing of Homologous Chromosomes.

Results and problems in cell differentiation

Hua LL, Casas CJ, Mikawa T

Avians as a Model System of Vascular Development.

Methods in molecular biology (Clifton, N.J.)

Asai R, Bressan M, Mikawa T