Anna Victoria Molofsky, MD, PhD

Associate Professor In Res
Department of Psychiatry
Research Overview: 

Astrocytes are intimately related to neuronal synapses, and are increasingly implicated in neurodevelopment and disease. Our lab studies astrocyte-neuron interactions at the molecular level by identifying novel astrocyte-encoded genes and studying their functional role in circuit and synapse formation during development. The finding that astrocytes are heterogeneous based on their location in the central nervous system provides a powerful tool to begin to identify novel astrocyte-encoded genes based on regional heterogeneity, and explore their functions in the developing nervous system. Using circuits in the developing spinal cord and other CNS regions, we study the role of specific astrocyte-encoded proteins on neuronal positioning, neuronal survival, and synapse formation. We are also interested in how astrocytes communicate with microglia to regulate synapse number and circuit function throughout the lifespan, and may serve as regulators of the innate immune system in the brain. These types of molecular studies will help to elucidate the role of astrocytes in psychiatric diseases of neural circuit formation, including schizophrenia, autism, and others.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Astrocytes in neural circuit formation and function

Websites

Publications: 

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.

Cell

Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV

Astrocytes and Microglia: In Sickness and in Health.

Trends in neurosciences

Vainchtein ID, Molofsky AV

Chapter 32 Mechanisms of astrocyte development.

Debosmita Sardar, Yi-Ting Cheng, Lukasz Mateusz Szewczyk, Benjamin Deneen, Anna Victoria Molofsky

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.

Immunity

Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB