Anna Victoria Molofsky, MD, PhD

Associate Professor In Res
Department of Psychiatry
Research Overview: 

Our group aims to understand the complex interactions between multiple cell types within the brain, including neurons, astrocytes, and microglia, and in particular, to define how innate immune signals shape healthy brain development, plasticty, and aging, both within the brain and in communication with peripheral immunity. Our goal is to achieve a cellular and molecular understanding of brain-immune communication that can inform new immune-based therapies for psychiatric, neurodevelopmental, and neurodegenerative illnesses.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Immunology
Research Summary: 
Brain-immune interactions throughout the lifespan
Mentorship Development: 

9/2020  Mentoring Across Differences
5/2021  Sharpening your Mentoring Skills (SyMS) 

Websites

Publications: 

Publisher Correction: Circuit and molecular architecture of a ventral hippocampal network.

Nature neuroscience

Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA

Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.

eLife

Kuhn J, Vainchtein ID, Braz JM, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky A, Molofsky A, Basbaum A

In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain.

Nature communications

Silva NJ, Dorman LC, Vainchtein ID, Horneck NC, Molofsky AV

Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH.

ACS sensors

Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW

Reactive astrocyte nomenclature, definitions, and future directions.

Nature neuroscience

Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A