eLife

Predicted glycosyltransferases promote development and prevent spurious cell clumping in the choanoflagellate S. rosetta.

eLife

Wetzel LA, Levin TC, Hulett RE, Chan D, King GA, Aldayafleh R, Booth DS, Sigg MA, King N

Genetic analysis reveals functions of atypical polyubiquitin chains.

eLife

Meza Gutierrez F, Simsek D, Mizrak A, Deutschbauer A, Braberg H, Johnson J, Xu J, Shales M, Nguyen M, Tamse-Kuehn R, Palm C, Steinmetz LM, Krogan NJ, Toczyski DP

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.

eLife

Hrit J, Goodrich L, Li C, Wang BA, Nie J, Cui X, Martin EA, Simental E, Fernandez J, Liu MY, Nery JR, Castanon R, Kohli RM, Tretyakova N, He C, Ecker JR, Goll M, Panning B

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

eLife

Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC

Motor thalamus supports striatum-driven reinforcement.

eLife

Lalive AL, Lien AD, Roseberry TK, Donahue CH, Kreitzer AC

Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.

eLife

Salisbury-Ruf CT, Bertram CC, Vergeade A, Lark DS, Shi Q, Heberling ML, Fortune NL, Okoye GD, Jerome WG, Wells QS, Fessel J, Moslehi J, Chen H, Roberts LJ, Boutaud O, Gamazon ER, Zinkel SS

Intrinsic cooperativity potentiates parallel cis-regulatory evolution.

eLife

Sorrells TR, Johnson AN, Howard CJ, Britton CS, Fowler KR, Feigerle JT, Weil PA, Johnson AD

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin.

eLife

Phillips AM, Doud MB, Gonzalez LO, Butty VL, Lin YS, Bloom JD, Shoulders MD

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