Tamara Alliston, PhD

Department of Orthopaedic Surgery
Research Overview: 

Our research focuses on the molecular pathways controlling mesenchymal stem cell differentiation, how these pathways coordinate with physical cues to influence mechanical integrity of normal skeletal tissue, and how they can be harnessed to repair tissue damaged in degenerative skeletal disease. In particular we focus on defining the function of TGFβ in coordinating physical and biochemical cues to regulate skeletal cell differentiation. To answer these questions we combine molecular, cellular, physiologic, and materials science approaches. This interdisciplinary approach will lead to the identification of targets to prevent skeletal disease or to improve skeletal repair.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Our research focuses on the molecular pathways controlling mesenchymal stem cell differentiation
Mentorship Development: 

10/20/20    Gathering in Community: a Training for Faculty and Staff
11/10/20    Optimizing the Efficiency of Your Lab
2/18/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels



Zoledronic acid improves bone quality and muscle function in a high bone turnover state.

bioRxiv : the preprint server for biology

Trivedi T, Manaa M, John S, Reiken S, Murthy S, Pagnotti GM, Dole NS, She Y, Suresh S, Hain BA, Regan J, Ofer R, Wright L, Robling A, Cao X, Alliston T, Marks AR, Waning DL, Mohammad KS, Guise TA

Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease.

Journal of bone metabolism

Schurman CA, Burton JB, Rose J, Ellerby LM, Alliston T, Schilling B