Tamara Alliston, PhD

Professor
Department of Orthopaedic Surgery
Research Overview: 

Our research focuses on the molecular pathways controlling mesenchymal stem cell differentiation, how these pathways coordinate with physical cues to influence mechanical integrity of normal skeletal tissue, and how they can be harnessed to repair tissue damaged in degenerative skeletal disease. In particular we focus on defining the function of TGFβ in coordinating physical and biochemical cues to regulate skeletal cell differentiation. To answer these questions we combine molecular, cellular, physiologic, and materials science approaches. This interdisciplinary approach will lead to the identification of targets to prevent skeletal disease or to improve skeletal repair.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Our research focuses on the molecular pathways controlling mesenchymal stem cell differentiation
Mentorship Development: 

10/20/20    Gathering in Community: a Training for Faculty and Staff
11/10/20    Optimizing the Efficiency of Your Lab
2/18/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels

Websites

Publications: 

Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-ß signaling.

Proceedings of the National Academy of Sciences of the United States of America

Schurman CA, Verbruggen SW, Alliston T

Altered canalicular remodeling associated with femur fracture in mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Emami AJ, Sebastian A, Lin YY, Yee CS, Osipov B, Loots GG, Alliston T, Christiansen BA

Fluid shear stress generates a unique signaling response by activating multiple TGFß family type I receptors in osteocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis Requires Osteocytic TGFß Signaling.

Arthritis & rheumatology (Hoboken, N.J.)

Bailey KN, Nguyen J, Yee CS, Dole NS, Dang A, Alliston T