John Rubenstein, MD, PhD

Professor
Department of Psychiatry
[email protected]
+1 415 476-7872
Research Overview: 

We study the following processes in the development mouse forebrain:

  • Mechanisms governing regional and cell type specification within the cortex and basal ganglia.
  • Transcriptional hierarchies, including identification of gene regulatory elements (enhancers), which govern cell fate decisions in the cerebral cortex, basal ganglia, and hypothalamus.
  • Molecular mechanisms controling cell migration.
  • Genetic studies of human neurogenetic disorders, such as Autism and Epilepsy.
Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Genetic Control of Development and Diseases of the Forebrain

Websites

Publications: 

Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.

Cell stem cell

Bershteyn M, Bröer S, Parekh M, Maury Y, Havlicek S, Kriks S, Fuentealba L, Lee S, Zhou R, Subramanyam G, Sezan M, Sevilla ES, Blankenberger W, Spatazza J, Zhou L, Nethercott H, Traver D, Hampel P, Kim H, Watson M, Salter N, Nesterova A, Au W, Kriegstein A, Alvarez-Buylla A, Rubenstein J, Banik G, Bulfone A, Priest C, Nicholas CR

Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis.

bioRxiv : the preprint server for biology

Catta-Preta R, Lindtner S, Ypsilanti A, Price J, Abnousi A, Su-Feher L, Wang Y, Juric I, Jones IR, Akiyama JA, Hu M, Shen Y, Visel A, Pennacchio LA, Dickel D, Rubenstein JLR, Nord AS

Machine learning dissection of human accelerated regions in primate neurodevelopment.

Neuron

Whalen S, Inoue F, Ryu H, Fair T, Markenscoff-Papadimitriou E, Keough K, Kircher M, Martin B, Alvarado B, Elor O, Laboy Cintron D, Williams A, Hassan Samee MA, Thomas S, Krencik R, Ullian EM, Kriegstein A, Rubenstein JL, Shendure J, Pollen AA, Ahituv N, Pollard KS