John Rubenstein, MD, PhD

Department of Psychiatry
+1 415 476-7872
Research Overview: 

We study the following processes in the development mouse forebrain:

  • Mechanisms governing regional and cell type specification within the cortex and basal ganglia.
  • Transcriptional hierarchies, including identification of gene regulatory elements (enhancers), which govern cell fate decisions in the cerebral cortex, basal ganglia, and hypothalamus.
  • Molecular mechanisms controling cell migration.
  • Genetic studies of human neurogenetic disorders, such as Autism and Epilepsy.
Primary Thematic Area: 
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Genetic Control of Development and Diseases of the Forebrain



DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.

Development (Cambridge, England)

Price JD, Lindtner S, Ypsilanti A, Binyameen F, Johnson JR, Newton BW, Krogan NJ, Rubenstein JLR

Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.

Nature neuroscience

Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X

Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.

Proceedings of the National Academy of Sciences of the United States of America

Su-Feher L, Rubin AN, Silberberg SN, Catta-Preta R, Lim KJ, Ypsilanti AR, Zdilar I, McGinnis CS, McKinsey GL, Rubino TE, Hawrylycz MJ, Thompson C, Gartner ZJ, Puelles L, Zeng H, Rubenstein JLR, Nord AS

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.

Development (Cambridge, England)

Su Z, Wang Z, Lindtner S, Yang L, Shang Z, Tian Y, Guo R, You Y, Zhou W, Rubenstein JL, Yang Z, Zhang Z

LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.

Journal of neurodevelopmental disorders

Fazel Darbandi S, Nelson AD, Pai EL, Bender KJ, Rubenstein JLR