John Rubenstein, MD

Professor
Department of Psychiatry
+1 415 476-7872
Research Overview: 

We study the following processes in the development mouse forebrain:

  • Mechanisms governing regional and cell type specification within the cortex and basal ganglia.
  • Transcriptional hierarchies, including identification of gene regulatory elements (enhancers), which govern cell fate decisions in the cerebral cortex, basal ganglia, and hypothalamus.
  • Molecular mechanisms controling cell migration.
  • Genetic studies of human neurogenetic disorders, such as Autism and Epilepsy.
Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Genetic Control of Development and Diseases of the Forebrain

Websites

Publications: 

A Chromatin Accessibility Atlas of the Developing Human Telencephalon.

Cell

Markenscoff-Papadimitriou E, Whalen S, Przytycki P, Thomas R, Binyameen F, Nowakowski TJ, Kriegstein AR, Sanders SJ, State MW, Pollard KS, Rubenstein JL

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.

eLife

Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz J, Vogt D, Paredes MF, Rubenstein JL

Lacz-Reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus.

The Journal of comparative neurology

Puelles L, Diaz C, Stühmer T, Ferran JL, Martínez-de la Torre M, Rubenstein JLR

Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.

Cell reports

Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR

Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.

Cell reports

Zhang Y, Liu G, Guo T, Liang XG, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein AR, Rubenstein JL, Yang Z, Chen B