Jill Hollenbach, PhD, MPH

Professor In Residence

Neurology

Research Description:

The Hollenbach Lab specializes in analysis of the extremely polymorphic human leukocyte antigen (HLA) and killer immunoglobulin-like receptor (KIR) immunogenetic systems. In addition to their critical role in transplantation, over 100 infectious, autoimmune and pharmacological disease phenotypes and cancers are associated with genetic variation of HLA and KIR, which also have functional interaction with one another. Our work spans the population genetics, evolutionary history, and influence on human health of these complex genomic regions, with particular emphasis on their role in neurological disease.

Primary Thematic Area:

Human Genetics

Secondary Thematic Area:

Immunology

Research Summary:

Our lab specializes in the analysis of highly polymorphic immunogenomic regions in the context of immune function, human health and disease, and evolutionary biology.

Websites

Hollenbach Lab

Featured Publications:

The immunogenetics of neurological disease.

Immunology

Misra MK, Damotte V, Hollenbach JA

A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America

Hollenbach JA, Norman PJ, Creary LE, Damotte V, Montero-Martin G, Caillier S, Anderson KM, Misra MK, Nemat-Gorgani N, Osoegawa K, Santaniello A, Renschen A, Marin WM, Dandekar R, Parham P, Tanner CM, Hauser SL, Fernandez-Viña M, Oksenberg JR

Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.

Journal of immunology (Baltimore, Md. : 1950)

Anderson KM, Augusto DG, Dandekar R, Shams H, Zhao C, Yusufali T, Montero-Martín G, Marin WM, Nemat-Gorgani N, Creary LE, Caillier S, Mofrad MRK, Parham P, Fernández-Viña M, Oksenberg JR, Norman PJ, Hollenbach JA

HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection.

medRxiv : the preprint server for health sciences

Augusto DG, Yusufali T, Peyser ND, Butcher X, Marcus GM, Olgin JE, Pletcher MJ, Maiers M, Hollenbach JA