Professor In Residence
Primary Thematic Area
M_Neurology
Secondary Thematic Area
Research Summary
Our lab specializes in the analysis of highly polymorphic immunogenomic regions in the context of immune function, human health and disease, and evolutionary biology.
The Hollenbach Lab specializes in analysis of the extremely polymorphic human leukocyte antigen (HLA) and killer immunoglobulin-like receptor (KIR) immunogenetic systems. In addition to their critical role in transplantation, over 100 infectious, autoimmune and pharmacological disease phenotypes and cancers are associated with genetic variation of HLA and KIR, which also have functional interaction with one another. Our work spans the population genetics, evolutionary history, and influence on human health of these complex genomic regions, with particular emphasis on their role in neurological disease.
Websites
Publications
The immunogenetics of neurological disease.
Immunology
A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America
Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.
Journal of immunology (Baltimore, Md. : 1950)
HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection.
medRxiv : the preprint server for health sciences