The Shy Lab employs cutting-edge genome and epigenome engineering techniques to address the current limitations in cell therapy development, manufacture, and delivery.
Basic and translational research of treatment resistance in cancers of the nervous system using high throughput functional genomics and epigenetic engineering approaches.
Using functional + spatial molecular tools to study post-transcriptional RNA + metabolic networks at single cell resolution and in 3D; Re-engineering/re-wiring cell fates for regenerative therapies
Elucidating the impact of the human gut microbiome on the treatment of autoimmune disease. Microbiology, translational studies with human samples, metagenomics, gnotobiotics, metabolomics, immunology.
Mentorship Development:
2017 - Scientific Leadership and Laboratory Management Course, UCSF
1/2022 - DEI Champion Training
10/2022 - UCSF-TRAIN-UP program (now called Inclusive Research Mentor/Manager Training)
2/2022 - Raising a Resilient Researcher (NIH-OITE)
Our lab leverages cutting-edge machine learning and experimental genomics to map the gene regulatory networks disrupted in cardiovascular disease and discover network-correcting therapeutics.
The Vasudevan Laboratory studies growth factor signaling through receptor tyrosine kinases and the Ras signaling pathway in development and cancer with an emphasis on neurofibromatosis.
