Brian Shy, MD, PhD

Asst Professor In Residence
Laboratory Medicine
[email protected]
+1 415 353-7359
Research Overview: 

Our research focuses on understanding these cellular engineering challenges and applying this knowledge to develop improved tools and processes that enhance the safety and effectiveness of cellular products. We apply these technologies to develop better treatments for a wide variety of indications, including inherited immune disorders, infectious diseases, and cancer. These efforts directly feed into our pre-clinical development and GMP manufacturing pipeline to make next-generation therapies rapidly available for our patients.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
The Shy Lab employs cutting-edge genome and epigenome engineering techniques to address the current limitations in cell therapy development, manufacture, and delivery.
Publications: 

SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci.

Nature biotechnology

Chang CR, Vykunta VS, Lee JHJ, Li K, Kochendoerfer C, Muldoon JJ, Wang CH, Mazumder T, Sun Y, Goodman DB, Nyberg WA, Liu C, Allain V, Rothrock A, Ye CJ, Marson A, Shy BR, Eyquem J

Central control of dynamic gene circuits governs T cell rest and activation.

Nature

Arce MM, Umhoefer JM, Arang N, Kasinathan S, Freimer JW, Steinhart Z, Shen H, Pham MTN, Ota M, Wadhera A, Dajani R, Dorovskyi D, Chen YY, Liu Q, Zhou Y, Swaney DL, Obernier K, Shy BR, Carnevale J, Satpathy AT, Krogan NJ, Pritchard JK, Marson A

Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal Leukoencephalopathy.

bioRxiv : the preprint server for biology

Gupta S, Martinov T, Thelen A, Sunahara M, Mureli S, Vazquez A, Gerdts J, Dandekar R, Cortese I, Fouassier C, Schanzer E, Urnov FD, Marson A, Shy BR, Greenberg PD, Wilson MR

Bidirectional epigenetic editing reveals hierarchies in gene regulation.

Nature biotechnology

Pacalin NM, Steinhart Z, Shi Q, Belk JA, Dorovskyi D, Kraft K, Parker KR, Shy BR, Marson A, Chang HY

Engineering an Escherichia coli strain for production of long single-stranded DNA.

Nucleic acids research

Shen K, Flood JJ, Zhang Z, Ha A, Shy BR, Dueber JE, Douglas SM