Alan Frankel, PhD

Professor
Department of Biochemistry and Biophysics
+1 415 476-9994
Research Overview: 

The Frankel Lab focuses on RNA-protein recognition and the assembly of RNA-based regulatory complexes. We use biochemistry, structural methods, proteomics, and virology to investigate two essential regulatory complexes in HIV: the viral Tat protein and its interactions with the host transcription machinery, and the viral Rev protein and its interactions with host nuclear export complexes. In concert with proteomic studies of HIV-human protein complexes, our studies have led to an understanding of how the virus has evolved adaptable protein interfaces to hijack these two host machines and establish a unique regulatory circuit that drives gene expression during the HIV life cycle.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
None
Research Summary: 
RNA-Protein Complexes

Websites

Publications: 

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

Cell host & microbe

Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ

Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability.

Scientific reports

Jayaraman B, Fernandes JD, Yang S, Smith C, Frankel AD

Discovery of a Branched Peptide that Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication.

Journal of medicinal chemistry

Dai Y, Wynn J, Peralta A, Sherpa C, Jayaraman B, Li H, Verma A, Frankel AD, Le Grice SFJ, Santos WL

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

eLife

Faust TB, Li Y, Bacon CW, Jang GM, Weiss A, Jayaraman B, Newton BW, Krogan NJ, D'Orso I, Frankel AD