Thea Mauro, MD

Professor
Department of Dermatology
Primary Thematic Area
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area
Developmental & Stem Cell Biology
Research Summary
Ionic Fluxes Control Keratinocyte Adhesion, Differentiation and Secretion
[email protected]
+1 415 750-2091 ext. 3371

My laboratory research has focused on defining ion channels, antiporters and Ca2+ ATP'ases which direct normal keratinocyte differentiation, adhesion, motility and secretion. Our laboratory has combined patch-clamp, ion sensitive dyes, PIXE and molecular biology approaches to study both cellular function and determine the role of these structures in human disease. Most recently, in collaboration with Dr. Ervin Epstein's laboratory, we have identified the mutation and functional consequences of a mutation in a Ca2+ ATP'ase, ATP2C1, which causes an blistering skin condition known as Hailey-Hailey disease. We also study ways to apply information gleaned from our laboratory studies to the treatment of human skin disease, including non-healing skin ulcers, bullous skin disease, and diseases of the epidermal permeability barrier, including atopic dermatitis and aged skin.

Publications

Ischemic Fasciitis Mimicking A Lipoma.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Saeed L, Bahrani E, Lauw MIS, Tabatabai ZL, Arron ST, Mauro TM

Basis for enhanced barrier function of pigmented skin.

The Journal of investigative dermatology

Man MQ, Lin TK, Santiago JL, Celli A, Zhong L, Huang ZM, Roelandt T, Hupe M, Sundberg JP, Silva KA, Crumrine D, Martin-Ezquerra G, Trullas C, Sun R, Wakefield JS, Wei ML, Feingold KR, Mauro TM, Elias PM

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America

Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ

Temporal dissection of tumorigenesis in primary cancers.

Cancer discovery

Durinck S, Ho C, Wang NJ, Liao W, Jakkula LR, Collisson EA, Pons J, Chan SW, Lam ET, Chu C, Park K, Hong SW, Hur JS, Huh N, Neuhaus IM, Yu SS, Grekin RC, Mauro TM, Cleaver JE, Kwok PY, LeBoit PE, Getz G, Cibulskis K, Aster JC, Huang H, Purdom E, Li J, Bolund L, Arron ST, Gray JW, Spellman PT, Cho RJ