Edward Hsiao, MD, PhD

Assistant Professor
Division of Endocrinology and Metabolism
Institute for Human Genetics
+1 415 476-9732
Research Description: 

EDUCATION/CLINICAL TRAINING
MD: MD, PhD, Johns Hopkins Medical School, 2001
Residency: Johns Hopkins Hospital, Baltimore, MD, Internal Medicine, 2001-2004
Fellowship: UCSF, Division of Diabetes, Endocrinology and Metabolism, 2004-2007
Board Certifications: Internal Medicine, 2004; Endocrinology and Metabolism, 2006

ACADEMIC INTERESTS
My research is driven by a desire to understand how major hormonal and regulatory pathways determine the specification, differentiation, and morphogenesis of mesenchymal tissues such as bone, cartilage, muscle, and fat. Mis-regulation of these pathways leads to significant medical diseases, including the inappropriate formation of mineralized tissues in atherosclerosis, heterotopic ossification, and cancer.

My research focuses on understanding how these regulatory signals control normal and pathologic tissue formation as a way to identifying new therapeutic avenues for treating human diseases. Our laboratory takes a comprehensive approach to understanding hormone signaling in human diseases using synthetic biology approaches, mouse models, and human stem cell models.

By combining multiple approaches with state-of-the art methods, our laboratory is working to develop a broader understanding of the biology underlying skeletal development, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect important tissues such as fat, muscle, bone, cartilage, and blood vessels.

CLINICAL INTERESTS:
General Endocrinology with an interest in inherited skeletal diseases, including fibrous dysplasia of the bone (FD), McCune-Albright syndrome (MAS), and fibrodysplasia ossificans progressiva (FOP).

Appointments: 415-353-2350
Availability: General Endocrinology, 3rd Tuesday PM of each month

Laboratory website: https://hsiaolab.ucsf.edu

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Hormonal and genetic regulation of human skeletal disease
Mentorship Development: 

4/30/20    Mental Health in a Pandemic: Q&A for Faculty
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels

Websites

Featured Publications: 

An ACVR1 activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.

Pain

Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells.

eLife

Barruet E, Garcia SM, Wu J, Morales BM, Tamaki S, Moody T, Pomerantz JH, Hsiao EC

Social and Clinical Impact of COVID-19 on Patients with Fibrodysplasia Ossificans Progressiva.

Research square

Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao E

ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.

Bone

Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC