Ryan Ash, MD, PhD | Biomedical Sciences Graduate Program

Assistant Professor

Primary Thematic Area

Neurobiology

M_Psych-Core-Rsch

Secondary Thematic Area

Tissue / Organ Biology & Endocrinology

Research Summary

Neural circuit therapeutics with transcranial focused ultrasound

Our lab advanced focused ultrasound techniques to rebalance synaptic stability and plasticity in neuropsychiatric disorders of excessive neural circuit stability, like autism, Tourette, PTSD, and others.

Publications

Empirical limitations of current low-intensity focused ultrasound simulation platforms.

medRxiv : the preprint server for health sciences

Brandts SD, Staveland BR, Madhusudhan A, Ash RT, Di Ianni T, Sugrue LP, Krystal AD, Moussawi K

Optimization of MR acoustic radiation force imaging (MR-ARFI) for human transcranial focused ultrasound.

Magnetic resonance in medicine

Mohammadjavadi M, Ash RT, Glover GH, Pauly KB

Stability of steady-state visual evoked potential contrast response functions.

Psychophysiology

Ash RT, Nix KC, Norcia AM

Transcranial ultrasound neuromodulation of the thalamic visual pathway in a large animal model and the dose-response relationship with MR-ARFI.

Scientific reports

Mohammadjavadi M, Ash RT, Li N, Gaur P, Kubanek J, Saenz Y, Glover GH, Popelka GR, Norcia AM, Pauly KB

MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning.

Molecular brain

Yue Y, Ash RT, Boyle N, Kinter A, Li Y, Zeng C, Lu H

Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ash RT, Palagina G, Fernandez-Leon JA, Park J, Seilheimer R, Lee S, Sabharwal J, Reyes F, Wang J, Lu D, Sarfraz M, Froudarakis E, Tolias AS, Wu SM, Smirnakis SM

Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit.

Science advances

Yue Y, Xu P, Liu Z, Sun X, Su J, Du H, Chen L, Ash RT, Smirnakis S, Simha R, Kusner L, Zeng C, Lu H

Inhibition of Elevated Ras-MAPK Signaling Normalizes Enhanced Motor Learning and Excessive Clustered Dendritic Spine Stabilization in the MECP2-Duplication Syndrome Mouse Model of Autism.

eNeuro

Ash RT, Buffington SA, Park J, Suter B, Costa-Mattioli M, Zoghbi HY, Smirnakis SM

Excessive Formation and Stabilization of Dendritic Spine Clusters in the MECP2-Duplication Syndrome Mouse Model of Autism.

eNeuro

Ash RT, Park J, Suter B, Zoghbi HY, Smirnakis SM

Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons.

Nature communications

Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM

Of Mice and Roentgen: Radiologist Satisfaction with a Non-conventional 13-Button Mouse-One Institution's Experience.

Journal of digital imaging

Denton K, Haider I, Hill J, Hunt SL, Ash R

Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome.

eNeuro

Ash RT, Fahey PG, Park J, Zoghbi HY, Smirnakis SM

Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model.

Neuron

Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY

Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.

Developmental cell

Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF

Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Jiang M, Ash RT, Baker SA, Suter B, Ferguson A, Park J, Rudy J, Torsky SP, Chao HT, Zoghbi HY, Smirnakis SM

Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo.

The European journal of neuroscience

Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL