Phillip Dumesic, MD, PhD

Assistant Prof in Residence
Diabetes Center
[email protected]
Research Description: 

We study how genes determine cellular decisions in energy metabolism, how organisms coordinate such decisions to maintain energy balance, and how new therapies might modulate these processes to treat diseases such as obesity, diabetes, sarcopenia, and cachexia. We apply genetics, biochemistry, and physiology—all driven by individual curiosity and diverse ways of thought.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Immunology
Research Summary: 
Genetic control of chemical energy in health and disease
Publications: 

RBM43 controls PGC1α translation and a PGC1α-STING signaling axis.

Cell metabolism

Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM

p38α kinase governs muscle strength through PGC1α in mice.

Acta physiologica (Oxford, England)

Herrera-Melle L, Cicuéndez B, López JA, Dumesic PA, Wilensky SE, Rodríguez E, Leiva-Vega L, Caballero A, León M, Vázquez J, Spiegelman BM, Folgueira C, Mora A, Sabio G

Remodeling p38 signaling in muscle controls locomotor activity via IL-15.

Science advances

Folgueira C, Herrera-Melle L, López JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, García-Culebras A, Dumesic PA, Rodríguez E, Leiva-Vega L, León M, Porteiro B, Iglesias C, Torres JL, Hernández-Cosido L, Bonacasa C, Marcos M, Moro MÁ, Vázquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G

Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.

Cell metabolism

Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer SM, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma AK, Balaz M, Wolfrum C, Spiegelman BM

REPTOR and CREBRF encode key regulators of muscle energy metabolism.

Nature communications

Saavedra P, Dumesic PA, Hu Y, Filine E, Jouandin P, Binari R, Wilensky SE, Rodiger J, Wang H, Chen W, Liu Y, Spiegelman BM, Perrimon N