Joseph Bondy-Denomy, PhD

Associate Professor
Microbiology and Immunology
+1 415 514-1381
Research Overview: 

In the Bondy-Denomy lab, we study and discover bacterial immune systems that antagonize bacteriophages (bacterial viruses). These systems include CRISPR-Cas, restriction-modification, and numerous other anti-phage defenses that are related to human innate immunity including cGAS-STING. We are very interested in how anti-phage defense works and the ways that phages fight back to survive in this ever raging arms race.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
CRISPR-Cas immunity and anti-immunity
Mentorship Development: 

4/11/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels

Websites

Publications: 

Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements.

Nucleic acids research

Tesson F, Huiting E, Wei L, Ren J, Johnson M, Planel R, Cury J, Feng Y, Bondy-Denomy J, Bernheim A

Single phage proteins sequester signals from TIR and cGAS-like enzymes.

Nature

Li D, Xiao Y, Fedorova I, Xiong W, Wang Y, Liu X, Huiting E, Ren J, Gao Z, Zhao X, Cao X, Zhang Y, Bondy-Denomy J, Feng Y

Diverse viral cas genes antagonize CRISPR immunity.

Nature

Katz MA, Sawyer EM, Oriolt L, Kozlova A, Williams MC, Margolis SR, Johnson M, Bondy-Denomy J, Meeske AJ

AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid.

bioRxiv : the preprint server for biology

Chen DF, Roe LT, Li Y, Borges AL, Zhang JY, Babbar P, Maji S, Stevens MGV, Correy GJ, Diolaiti ME, Smith DH, Ashworth A, Stroud RM, Kelly MJS, Bondy-Denomy J, Fraser JS

Exploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elements.

bioRxiv : the preprint server for biology

Tesson F, Huiting E, Wei L, Ren J, Johnson MC, Planel R, Cury J, Feng Y, Bondy-Denomy J, Bernheim A