Aaron Bodansky, MD

photo of Dr. Aaron Bodansky
Assistant Professor
Primary Thematic Area
M_PEDS-CRITICAL CARE
Secondary Thematic Area
Research Summary
We develop and apply advanced immune-profiling technologies to define mechanisms of severe and enigmatic immune-mediated disease, with a particular focus on children.

I am a pediatric critical care physician-scientist studying severe and enigmatic immune-mediated disease, with a particular focus on disorders of childhood. My laboratory develops and applies advanced technologies in immune profiling, antibody and antigen discovery, single-cell genomics and pathogen detection to uncover the mechanisms underlying autoimmunity, hyperinflammation and post-infectious disease. Our goal is to translate these discoveries into antigen-defined diagnostics, biomarkers of disease and response, and more precise, mechanism-directed therapies.

Publications

Neuroinvasive Trichodysplasia Spinulosa-Associated Polyomavirus Infection.

The New England journal of medicine

Bodansky A, Pierson N, Servellita V, Marquis K, Valdovinos R, Hiermandi N, Bollen AW, Caliskan I, Mirchia K, Omura C, Streithorst J, LaFranchi B, Henrich TJ, Wang CY, Castillo-Rojas B, Bernal W, Bicki A, Winnicki E, Lee M, Zorn K, Sidhu S, Glenn O, Karalius M, Zinter MS, Nash K, Wilson MR, Tarro TM, DeRisi JL, Chiu CY

High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.

Proceedings of the National Academy of Sciences of the United States of America

Gervais A, Marchal A, Maillard A, Le Voyer T, Rosain J, Philippot Q, Bizien L, Peel J, Cederholm A, Migaud M, Pons S, Saker K, Laforet P, Aubart M, Gitiaux C, Biggs CM, Lopez RL, Souvannanorath S, Tard C, Pakleza AN, Grapperon AM, Heming N, Annane D, Verschueren A, Attarian S, Bigaut K, Hankiewicz K, Kouton L, Villar-Quiles RN, Cauquil C, Fleury MC, Rocher E, Nicolas G, de Paula Estephan E, da Penha Ananias Morita M, Zanoteli E, Saied Z, Rachdi A, Rim A, Belal S, Ben Sassi S, Hübers A, Faure E, Desguerre I, Basse C, Girard N, Béziat V, Pan-Hammarström Q, Hammarström L, Bodansky A, Parent AV, Anderson MS, DeRisi JL, Demeret S, Truffault F, Fort R, Ader F, Wallet F, Trouillet-Assant S, Abel L, Molina T, Alyanakian MA, Le Panse R, Solé G, Cobat A, Landegren N, Casanova JL, Puel A, Bastard P, Jouanguy E

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD.

bioRxiv : the preprint server for biology

Bodansky A, Ahyong V, Dayao M, Asaki J, Vanasupa S, Dandekar R, Chen S, Sabatino J, Klauer S, Knudsen G, Lizama Valenzuela C, McCutcheon K, Zorn K, Sidhu S, Yu D, Garcia S, Quandt Z, Wang CY, Castillo Rojas B, Tilton I, Citron YR, Sharathchandra A, Gerungan C, Tomko S, Robbins NM, McKeon A, Cooper T, Harms M, Gomez R, Fancy SPJ, Green AJ, Caliskan I, Cadwell CR, Ostrem BE, Karalius M, Braun L, Gupta S, Francisco C, Peng G, Reddy AT, Nash K, Pleasure SJ, Mandel-Brehm C, Arnold TD, Consortium, Anderson MS, Gerdts J, Wilson MR, DeRisi JL

High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.

medRxiv : the preprint server for health sciences

Gervais A, Marchal A, Maillard A, Le Voyer T, Rosain J, Philipot Q, Bizien L, Peel J, Cederholm A, Migaud M, Pons S, Saker K, Laforet P, Aubart M, Gitiaux C, Biggs C, Leon Lopez R, Souvannanorath S, Tard C, Nadaj Pakleza A, Grapperon AM, Heming N, Annane D, Verschueren A, Attarian S, Bigaut K, Hankiewicz K, Kouton L, Villar-Quiles RN, Cauquil C, Fleury MC, Rocher E, Nicolas G, de Paula Estephan E, da Penha Ananias Morita M, Zanoteli E, Saied Z, Rachdi A, Rim A, Belal S, Ben Sassi S, Hübers A, Faure E, Desguerre I, Basse C, Girard N, Béziat V, Pan-Hammarström Q, Hammarström L, Bodansky A, Parent AV, Anderson MS, DeRisi JL, Demeret S, Truffault F, Fort R, Ader F, Wallet F, Abel L, Molina T, Alyanakian MA, Le Panse R, Solé G, Cobat A, Landegren N, Casanova JL, Puel A, Bastard P, Jouanguy E

Molecular mimicry in multisystem inflammatory syndrome in children.

Nature

Bodansky A, Mettelman RC, Sabatino JJ, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn K, Yu DJL, Pogorelyy MV, Awad W, Kirk AM, Asaki J, Pluvinage JV, Wilson MR, Zambrano LD, Campbell AP, Overcoming COVID-19 Network Investigators, Thomas PG, Randolph AG, Anderson MS, DeRisi JL

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency.

The Journal of experimental medicine

Chan YH, Lundberg V, Le Pen J, Yuan J, Lee D, Pinci F, Volpi S, Nakajima K, Bondet V, Åkesson S, Khobrekar NV, Bodansky A, Du L, Melander T, Mariaggi AA, Seeleuthner Y, Saleh TS, Chakravarty D, Marits P, Dobbs K, Vonlanthen S, Hennings V, Thörn K, Rinchai D, Bizien L, Chaldebas M, Sobh A, Özçelik T, Keles S, AlKhater SA, Prando C, Meyts I, COVID Human Genetic Effort, Wilson MR, Rosain J, Jouanguy E, Aubart M, Abel L, Mogensen TH, Pan-Hammarström Q, Gao D, Duffy D, Cobat A, Berg S, Notarangelo LD, Harschnitz O, Rice CM, Studer L, Casanova JL, Ekwall O, Zhang SY

Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency.

Science translational medicine

Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, Bartley CM, Kondapavulur S, Hurabielle C, Bodansky A, Pai V, Hinman S, Aslanpour A, Alvarenga BD, Zorn KC, Zamecnik C, McCann A, Asencor AI, Huynh T, Browne W, Tubati A, Haney MS, Douglas VC, Louine M, Cree BAC, Hauser SL, Seeley W, Baranzini SE, Wells JA, Spudich S, Farhadian S, Ramachandran PS, Gillum L, Hales CM, Zikherman J, Anderson MS, Yazdany J, Smith B, Nath A, Suh G, Flanagan EP, Green AJ, Green R, Gelfand JM, DeRisi JL, Pleasure SJ, Wilson MR

Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR-T therapies in autoimmunity.

The Journal of clinical investigation

Bodansky A, Yu DJ, Rallistan AN, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn KC, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Saloner R, Casaletto KB, Gontrum EQ, Chan BJ, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL

Rare neutralizing IFN-γ autoantibodies in HLA-DRB1* 15:02 or 16:02 individuals confer susceptibility to mycobacterial infections.

The Journal of clinical investigation

Peel JN, Yang R, Le Voyer T, Gervais A, Rosain J, Bastard P, Behere A, Cederholm A, Bodansky A, Seeleuthner Y, Conil C, Ding JY, Lei WT, Bizien L, Soudee C, Migaud M, Ogishi M, Yatim A, Lee D, Bohlen J, Perpoint T, Perez L, Messina F, Genet R, Karkowski L, Blot M, Lafont E, Toullec L, Goulvestre C, Mehlal-Sedkaoui S, Sallette J, Martin F, Puel A, Jouanguy E, Anderson MS, Landegren N, Tiberghien P, Abel L, Boisson-Dupuis S, Bustamante J, Ku CL, Casanova JL

Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy.

medRxiv : the preprint server for health sciences

Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL

NFKB2 haploinsufficiency identified via screening for IFNa2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications.

The Journal of allergy and clinical immunology

Bodansky A, Vazquez SE, Chou J, Novak T, Al-Musa A, Young C, Newhams M, Kucukak S, Zambrano LD, Mitchell A, Wang CY, Moffitt K, Halasa NB, Loftis LL, Schwartz SP, Walker TC, Mack EH, Fitzgerald JC, Gertz SJ, Rowan CM, Irby K, Sanders RC, Kong M, Schuster JE, Staat MA, Zinter MS, Cvijanovich NZ, Tarquinio KM, Coates BM, Flori HR, Dahmer MK, Crandall H, Cullimore ML, Levy ER, Chatani B, Nofziger R, Overcoming COVID-19 Network Study Group Investigators, Geha RS, DeRisi J, Campbell AP, Anderson M, Randolph AG

Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq.

eLife

Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Proekt I, Yu D, Mandel-Brehm C, Wang CY, Miao B, Sowa G, Zorn K, Chan AY, Tagi VM, Shimizu C, Tremoulet A, Lynch K, Wilson MR, Kämpe O, Dobbs K, Delmonte OM, Bacchetta R, Notarangelo LD, Burns JC, Casanova JL, Lionakis MS, Torgerson TR, Anderson MS, DeRisi JL