Alzheimer's & Dementia

KLOTHO KL-VS genotype modifies the relationship between cardiorespiratory fitness and CSF biomarkers of neurodegeneration, synaptic dysfunction, and inflammation.

Alzheimer's & Dementia

Mackenzie Jarchow, Ira Driscoll, Brianne M. Breidenbach, Noah R. Cook, Catherine L. Gallagher, Sterling C. Johnson, Sanjay Asthana, Bruce P Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dane B. Cook, Dena B. Dubal, Ozioma C Okonkwo

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Alzheimer's & Dementia

Aradhana Sachdev, Kamaljot Gil, Maria Sckaff, Alisha M Birk, Olubankole Aladesuyi Arogundade, Katherine A Brown, Runvir S Chouhan, Patrick Issagholian Lewin, Esha Patel, Kathleen Keough, Bruce Conklin, Alec ST Smith, Claire Clelland

Uncovering mechanisms of hyperexcitability in tauopathies with functional genomics.

Alzheimer's & Dementia

Steven C Boggess, Vaidehi Gandhi, Ming-Chi Tsai, Yu-Ying Chou, Jesse E. Hanson, Martin Kampmann

Exploring selective neuronal vulnerability in Alzheimer’s disease – key pathways are downregulated in vulnerable subpopulations of RORB and CDH9 excitatory neurons of the entorhinal cortex at Braak 0.

Alzheimer's & Dementia

Alexander V. Soloviev, Felipe Luiz Pereira, Renata Elaine Paraizo Leite, Claudia Kimie Suemoto, Kun Leng, Martin Kampmann, Lea T. Grinberg

Systemic Mechanisms of Brain Aging and Rejuvenation.

Alzheimer's & Dementia

Saul Villeda

Neuronal Calcium-Sensing Receptor Is A Druggable Target To Treat Alzheimer’s Disease.

Alzheimer's & Dementia

Chia-Ling Tu, Kota Kurisu, Zhiqiang Cheng, Stephanie R Miller, Atushi Mizuma, Jialing Liu, Jorge J Palop, Lea T. Grinberg, Midori A Yenari, Wenhan Chang

KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.

Alzheimer's & Dementia

Ira Frahmand Driscoll, Sarah Lose, Yue Ma, Barbara B. Bendlin, Catherine Gallagher, Sterling C. Johnson, Sanjay Asthana, Bruce Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dena Dubal, Ozioma C. Okonkwo

Machine Learning Approach to Identify Dysregulation in the Plasma Proteome of CADASIL.

Alzheimer's & Dementia

Jonah Keller, Stephen Fitzsimons, Ryan Park, Luana Moury, Bradley C Oh, Scott Treiman, Hannah Radabaugh, Adam Ferguson, Fanny M Elahi

Machine Learning Approach to Identify Dysregulation in the Plasma Proteome of CADASIL.

Alzheimer's & Dementia

Jonah Keller, Stephen Fitzsimons, Ryan Park, Luana Moury, Bradley C Oh, Scott Treiman, Hannah Radabaugh, Adam Ferguson, Fanny M Elahi

Plasma rejuvenation factor GDF11 associates with amyloid-related cognitive decline in older adults across the Alzheimer’s Disease spectrum.

Alzheimer's & Dementia

Shannon Y. Lee, Emily W. Paolillo, Rowan Saloner, Anna M VandeBunte, Gil D. Rabinovici, Renaud La Joie, Joel H. Kramer, Saul Villeda, Kaitlin B. Casaletto

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