Gastroenterology

630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS.

Gastroenterology

Elvira Mennillo, Yang Joon Kim, Iulia Rusu, Gyehyun Lee, Leah Dorman, Faviola Bernard-Vazquez, Jared Bain, Ravi K. Patel, Christopher Andersen, Stanley Tamaki, Jessica Tsui, Kendall Beck, Najwa El-Nachef, Sara M. Lewin, Daniel Selvig, Jonathan P. Terdiman, Uma Mahadevan, David Oh, Gabriela K. Fragiadakis, Angela O. Pisco, Alexis Combes, Michael Kattah

Anti-Integrin av�6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis.

Gastroenterology

Livanos AE, Dunn A, Fischer J, Ungaro RC, Turpin W, Lee SH, Rui S, Del Valle DM, Jougon JJ, Martinez-Delgado G, Riddle MS, Murray JA, Laird RM, Torres J, Agrawal M, Magee JS, Dervieux T, Gnjatic S, Sheppard D, Sands BE, Porter CK, Croitoru K, Petralia F, CCC-GEM Project Research Consortium, OSCCAR Consortium, Colombel JF, Mehandru S

Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM.

Gastroenterology

Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. Klein, Alexander Marson, Jessie A. Turnbaugh, Peter J. Turnbaugh, Barbara Malynn, Averil Ma, Michael Kattah

Abnormal TP53 Predicts Risk of Progression in Patients With Barrett's Esophagus Regardless of a Diagnosis of Dysplasia.

Gastroenterology

Redston M, Noffsinger A, Kim A, Akarca FG, Rara M, Stapleton D, Nowden L, Lash R, Bass AJ, Stachler MD

Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK blockade and CD40 Agonism.

Gastroenterology

Jiang H, Courau T, Borison J, Ritchie AJ, Mayer AT, Krummel MF, Collisson EA

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-induced Pancreatic Cancer Progression.

Gastroenterology

Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK

Deleterious variants in ABCC12 are detected in idiopathic chronic cholestasis and cause intrahepatic bile duct loss in model organisms: ABCC12 pathogenic variants lead to cholestasis.

Gastroenterology

Pham DH, Kudira R, Xu L, Valencia CA, Ellis JL, Shi T, Evason KJ, Osuji I, Matuschek N, Pfuher L, Mullen M, Mohanty SK, Husami A, Bull LN, Zhang K, Wali S, Yin C, Miethke A

iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile.

Gastroenterology

Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ

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