Ying-Hui Fu, PhD

Department of Neurology
+1 415 502-2948
Research Description: 

Dr. Fu’s research uses human genetics combined with multiple model organisms to investigate molecular mechanisms of human conditions. Her laboratory has been focusing on two areas: one in myelin biology and the other in circadian rhythm and sleep behaviors. For myelin biology, they investigate the interlocking networks of protein-coding genes and non-coding RNAs in ensuring a healthy myelin. For circadian and sleep behaviors, over the last 15 years, she and her colleagues identified several mutations that lead to extreme morning lark phenotype. In addition, they are investigating the genetic basis for human subjects to have shorter sleep duration. Since circadian rhythm and sleep homeostasis are intimately connected with many physiological pathways including metabolism, immune function, and mood regulation, to name but a few, these studies will also shed new light on how sleep schedule and sleep homeostasis can impact on health.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Research Summary: 
Molecular understanding of human sleep behaviors



Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation.

Science translational medicine

Xing L, Shi G, Mostovoy Y, Gentry NW, Fan Z, McMahon TB, Kwok PY, Jones CR, Ptácek LJ, Fu YH

A Rare Mutation of ß1-Adrenergic Receptor Affects Sleep/Wake Behaviors.


Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptácek LJ, Fu YH

Genetics of the human circadian clock and sleep homeostat.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Ashbrook LH, Krystal AD, Fu YH, Ptácek LJ

TIMELESS mutation alters phase responsiveness and causes advanced sleep phase.

Proceedings of the National Academy of Sciences of the United States of America

Kurien P, Hsu PK, Leon J, Wu D, McMahon T, Shi G, Xu Y, Lipzen A, Pennacchio LA, Jones CR, Fu YH, Ptácek LJ

DEC2 modulates orexin expression and regulates sleep.

Proceedings of the National Academy of Sciences of the United States of America

Hirano A, Hsu PK, Zhang L, Xing L, McMahon T, Yamazaki M, Ptácek LJ, Fu YH