Ying-Hui Fu, PhD

Professor
Department of Neurology
+1 415 514-9310
Research Description: 

Dr. Fu’s research uses human genetics combined with multiple model organisms to investigate molecular mechanisms of human conditions. Her laboratory has been focusing on two areas: one in myelin biology and the other in circadian rhythm and sleep behaviors. For myelin biology, they investigate the interlocking networks of protein-coding genes and non-coding RNAs in ensuring a healthy myelin. For circadian and sleep behaviors, over the last 15 years, she and her colleagues identified several mutations that lead to extreme morning lark phenotype. In addition, they are investigating the genetic basis for human subjects to have shorter sleep duration. Since circadian rhythm and sleep homeostasis are intimately connected with many physiological pathways including metabolism, immune function, and mood regulation, to name but a few, these studies will also shed new light on how sleep schedule and sleep homeostasis can impact on health.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Neurobiology
Research Summary: 
Molecular understanding of human sleep behaviors

Websites

Publications: 

Recent advances in sleep genetics.

Current opinion in neurobiology

Webb JM, Fu YH

Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.

Current biology : CB

Shi G, Yin C, Fan Z, Xing L, Mostovoy Y, Kwok PY, Ashbrook LH, Krystal AD, Ptácek LJ, Fu YH

A Mitochondrial tRNA Mutation Causes Axonal CMT in a Large Venezuelan Family.

Annals of neurology

Fay AJ, Garcia Y, Margeta M, Maharjan S, Jürgensen C, Briceño J, Garcia M, Yin S, Bassaganyas L, McMahon T, Hou YM, Fu YH, Ptácek LJ

Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation.

Science translational medicine

Xing L, Shi G, Mostovoy Y, Gentry NW, Fan Z, McMahon TB, Kwok PY, Jones CR, Ptácek LJ, Fu YH

A Rare Mutation of ß1-Adrenergic Receptor Affects Sleep/Wake Behaviors.

Neuron

Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptácek LJ, Fu YH