
Associate Investigator, Gladstone Institutes of Cardiovascular Disease and Neurological Disease
Professor
Department of Neurology
Primary Thematic Area
Secondary Thematic Area
Research Summary
Molecular Mechanisms and Therapeutic Strategies of Neurodegenerative Diseases
Mentorship Development
5/2021 - Sharpening your Mentoring Skills (SyMS)
9/2021 - Disabilities Awareness Training
+1 415 734-2511
Publications
Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms.
Annual review of pathology
An Alzheimer's-disease-protective APOE mutation.
Nature medicine
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease.
Molecular neurodegeneration
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Nature medicine
Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.
PLoS medicine
Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.
Stem cell reports
Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.
Cell stem cell
Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Direct Reprogramming of RESTing Astrocytes.
Cell stem cell
Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives.
Experimental & molecular medicine
Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.
Neurobiology of disease
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aß accumulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.
Stem cell reports
Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients.
Journal of neurology, neurosurgery, and psychiatry
Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology.
Journal of medicinal chemistry
Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development.
PloS one
Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One
Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One.
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.
Cell stem cell
Reducing human apolipoprotein E levels attenuates age-dependent Aß accumulation in mutant human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.
The Journal of biological chemistry
Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.
Biochemical Society transactions
Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.
The Journal of biological chemistry
C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.
Proceedings of the National Academy of Sciences of the United States of America
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.
The Journal of biological chemistry
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases.
Current opinion in lipidology
Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice.
The American journal of pathology
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
Trends in molecular medicine
GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.
Cell stem cell
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
Journal of neurochemistry
Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches.
Annals of neurology
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Journal of lipid research
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America
Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.
Proceedings of the National Academy of Sciences of the United States of America
Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.
Current Alzheimer research
Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.
The Journal of clinical investigation
Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.
Current opinion in drug discovery & development
Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).
The pharmacogenomics journal
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Putting cholesterol in its place: apoE and reverse cholesterol transport.
The Journal of clinical investigation
Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America
Apolipoprotein E and Alzheimer disease.
Neurology
Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.
Acta neurologica Scandinavica. Supplementum
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
The Journal of biological chemistry
Effect of domain interaction on apolipoprotein E levels in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.
Journal of lipid research
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
The Journal of biological chemistry
ApoE genotype accounts for the vast majority of AD risk and AD pathology.
Neurobiology of aging
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.
The Journal of biological chemistry
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.
The Journal of biological chemistry
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.
Journal of lipid research
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
The Journal of biological chemistry
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Proceedings of the National Academy of Sciences of the United States of America
Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages.
Journal of molecular medicine (Berlin, Germany)
Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.
Arteriosclerosis, thrombosis, and vascular biology
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Journal of lipid research
Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond.
Current opinion in lipidology
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.
The Journal of biological chemistry
Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins.
The Journal of biological chemistry
Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
The Journal of clinical investigation
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.
Arteriosclerosis, thrombosis, and vascular biology
Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.
The Journal of biological chemistry
A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma.
Journal of lipid research
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
The Journal of biological chemistry
Phospholipid transfer protein mediated conversion of high density lipoproteins generates pre beta 1-HDL.
Biochimica et biophysica acta
Uptake, transfer, and esterification of cell-derived cholesterol in plasma of patients with familial HDL-deficiency.
Zeitschrift fur Gastroenterologie
Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.
The Journal of clinical investigation
Generation of pre-beta 1-HDL and conversion into alpha-HDL. Evidence for disturbed HDL conversion in Tangier disease.
Arteriosclerosis, thrombosis, and vascular biology
Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma.
Arteriosclerosis, thrombosis, and vascular biology
Cholesterol efflux, cholesterol esterification, and cholesteryl ester transfer by LpA-I and LpA-I/A-II in native plasma.
Arteriosclerosis, thrombosis, and vascular biology
Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency.
Arteriosclerosis, thrombosis, and vascular biology
Physiological role and clinical relevance of high-density lipoprotein subclasses.
Current opinion in lipidology
A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells.
Proceedings of the National Academy of Sciences of the United States of America
Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma.
Arteriosclerosis and thrombosis : a journal of vascular biology