Thea Mauro, MD

Professor
Department of Dermatology
+1 415 750-2091 ext. 3371
Research Overview: 

My laboratory research has focused on defining ion channels, antiporters and Ca2+ ATP'ases which direct normal keratinocyte differentiation, adhesion, motility and secretion. Our laboratory has combined patch-clamp, ion sensitive dyes, PIXE and molecular biology approaches to study both cellular function and determine the role of these structures in human disease. Most recently, in collaboration with Dr. Ervin Epstein's laboratory, we have identified the mutation and functional consequences of a mutation in a Ca2+ ATP'ase, ATP2C1, which causes an blistering skin condition known as Hailey-Hailey disease. We also study ways to apply information gleaned from our laboratory studies to the treatment of human skin disease, including non-healing skin ulcers, bullous skin disease, and diseases of the epidermal permeability barrier, including atopic dermatitis and aged skin.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Ionic Fluxes Control Keratinocyte Adhesion, Differentiation and Secretion
Publications: 

The link between cutaneous inflammation and cognitive impairment.

Journal of the European Academy of Dermatology and Venereology : JEADV

Wen S, Elias PM, Wakefield JS, Mauro TM, Man MQ

Classification of human chronic inflammatory skin disease based on single-cell immune profiling.

Science immunology

Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB

Regulatory Role of Nitric Oxide in Cutaneous Inflammation.

Inflammation

Man MQ, Wakefield JS, Mauro TM, Elias PM

Epidermal Basement Membrane Substitutes for Bioengineering of Human Epidermal Equivalents.

JID innovations : skin science from molecules to population health

Kolundzic N, Khurana P, Crumrine D, Celli A, Mauro TM, Ilic D

Role of nitric oxide in regulating epidermal permeability barrier function.

Experimental dermatology

Man MQ, Wakefield JS, Mauro TM, Elias PM