Thea Mauro, MD

Department of Dermatology
+1 415 750-2091 ext. 3371
Research Overview: 

My laboratory research has focused on defining ion channels, antiporters and Ca2+ ATP'ases which direct normal keratinocyte differentiation, adhesion, motility and secretion. Our laboratory has combined patch-clamp, ion sensitive dyes, PIXE and molecular biology approaches to study both cellular function and determine the role of these structures in human disease. Most recently, in collaboration with Dr. Ervin Epstein's laboratory, we have identified the mutation and functional consequences of a mutation in a Ca2+ ATP'ase, ATP2C1, which causes an blistering skin condition known as Hailey-Hailey disease. We also study ways to apply information gleaned from our laboratory studies to the treatment of human skin disease, including non-healing skin ulcers, bullous skin disease, and diseases of the epidermal permeability barrier, including atopic dermatitis and aged skin.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Ionic Fluxes Control Keratinocyte Adhesion, Differentiation and Secretion

Link between the skin and autism spectrum disorder.

Frontiers in psychiatry

Man MQ, Yang S, Mauro TM, Zhang G, Zhu T

Association of Epidermal Biophysical Properties with Obesity and its Implications.

Skin pharmacology and physiology

Zhu T, Yang S, Mauro TM, Man MQ

Sodium in the Skin: A summary of the physiology and scoping review of disease associations.

Clinical and experimental dermatology

Chattopadhyay A, Tully J, Shan J, Sheikh S, Ohliger M, Gordon J, Mauro T, Abuabara K

Link between obesity and atopic dermatitis: Does obesity predispose to atopic dermatitis, or vice versa?

Experimental dermatology

Yang S, Zhu T, Wakefield JS, Mauro TM, Elias PM, Man MQ

Skin Barrier Function and Cognition Among Older Adults.

The Journal of investigative dermatology

Kim RW, An Y, Zukley L, Ferrucci L, Mauro T, Yaffe K, Resnick SM, Abuabara K