Thea Mauro, MD

Professor
Department of Dermatology
+1 415 750-2091 ext. 3371
Research Overview: 

My laboratory research has focused on defining ion channels, antiporters and Ca2+ ATP'ases which direct normal keratinocyte differentiation, adhesion, motility and secretion. Our laboratory has combined patch-clamp, ion sensitive dyes, PIXE and molecular biology approaches to study both cellular function and determine the role of these structures in human disease. Most recently, in collaboration with Dr. Ervin Epstein's laboratory, we have identified the mutation and functional consequences of a mutation in a Ca2+ ATP'ase, ATP2C1, which causes an blistering skin condition known as Hailey-Hailey disease. We also study ways to apply information gleaned from our laboratory studies to the treatment of human skin disease, including non-healing skin ulcers, bullous skin disease, and diseases of the epidermal permeability barrier, including atopic dermatitis and aged skin.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Ionic Fluxes Control Keratinocyte Adhesion, Differentiation and Secretion
Publications: 

Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.

Immunity

Mathur AN, Zirak B, Boothby IC, Tan M, Cohen JN, Mauro TM, Mehta P, Lowe MM, Abbas AK, Ali N, Rosenblum MD

Disseminated cutaneous Cryptococcus clinically mimicking basal cell carcinoma.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Murakawa GJ, Mauro TM, Egbert B

Mal de Meleda in a Laotian family.

International journal of dermatology

Chotzen VA, Starr JC, Mauro TM

Autologous skin grafts for leg ulcers.

The Western journal of medicine

Mauro TM