Sulggi Lee, MD, PhD

Associate Professor
Medicine
+1 415 735-5127
Research Description: 

Sulggi Lee, MD PhD, is an Associate Professor of Medicine at the University of California, San Francisco (UCSF) and a faculty member in the Division of HIV, Infectious Diseases, and Global Medicine at the Zuckerberg San Francisco General Hospital. She is the PI of the UCSF Treat Acute HIV study, Co-PI of the UCSF SCOPE HIV cohort, the PI of the COVID-19 Host Immune Response Pathogenesis (CHIRP) study, Co-PI of the UCSF AIDS Cancer Specimen Resource (ACSR), and Co-Director of the UCSF Center for AIDS Research (CFAR) Bioinformatics Core. She is one of the founding executive committee members of the UCSF Women's Physician Scientist Supergroup (WPSS) and a faculty mentor for the UCSF Medical Scientist Training Program (MSTP) Community of Underrepresented Physician Scientists (CUPS) program. Her research focuses on clinical translational studies aimed at determining how natural host responses to pathogens (e.g., HIV, SARS-CoV-2) can be leveraged as future therapeutic targets using discovery-based analytic approaches. Her collaborative, interdisciplinary team includes data scientists, immunologists, virologists, and clinicians. Her work involves the application of highly advanced laboratory assays to well-characterized patient samples from observational studies and clinical trials. The goal of her research is to identify underlying host mechanisms of pathogen control to enable the identification of potential novel therapeutic targets for reducing morbidity and mortality associated with HIV and COVID-19.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
Clinical translational research to identify host genetic and immunologic predictors of infectious diseases (e.g., HIV and SARS-CoV-2) using high dimensional single cell and systems biology approaches.

Websites

Featured Publications: 

SARS-CoV-2-specific T cells exhibit unique features characterized by robust helper function, lack of terminal differentiation, and high proliferative potential.

bioRxiv : the preprint server for biology

Neidleman J, Luo X, Frouard J, Xie G, Gurjot G, Stein ES, McGregor M, Ma T, George AF, Kosters A, Greene WC, Vasquez J, Ghosn E, Lee S, Roan NR

Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.

Journal of acquired immune deficiency syndromes (1999)

Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

PLoS pathogens

Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.

Clinical pharmacology and therapeutics

Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM

Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy.

The Journal of infectious diseases

Lee S, Byakwaga H, Boum Y, Burdo TH, Williams KC, Lederman MM, Huang Y, Tracy RP, Cao H, Haberer JE, Kembabazi A, Bangsberg DR, Martin JN, Hunt PW

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.

PloS one

Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD

Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.

AIDS (London, England)

Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL

Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.

The Journal of infectious diseases

Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW

Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging.

PloS one

Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW