Sulggi Lee, MD, PhD

Sulggi Lee, MD PhD, is an Associate Professor of Medicine in Residence at the University of California, San Francisco (UCSF) and a faculty member in the Division of HIV, Infectious Diseases, and Global Medicine at the Zuckerberg San Francisco General Hospital. She is Co-PI of the UCSF SCOPE HIV cohort which includes over 2,500+ HIV+ participants, the PI of the UCSF Acute HIV study (individuals diagnosed within 100 days of infection), the PI of the acute COVID-19 Host Immune Response Pathogenesis (CHIRP) study (over 300 longitudinal specimens from recently COVID-19 convalescent individuals in the outpatient setting), and the Clinical Core Director of the UCSF amfAR HIV Cure Institute. Her lab investigates the role of host genetics and immunology in infectious diseases pathogenesis and persistence using a variety of high-throughput sequencing methods (whole exome DNA sequencing, single-cell RNA and antibody sequencing) and discovery-based ‘multi-omic’ analytic approaches. Her work leverages patients samples from observational and clinical trials to identify novel targets for the treatment of infectious diseases. This work includes research focused on host-specific drug responses to interventions (e.g., HIV cure interventional trials) using pharmacokinetic/ pharmacodynamic modeling and research to identify genetic and immunologic signatures that predict extreme clinical phenotypes (e.g., HIV “elite” controllers who are able to suppress virus in the absence of therapy or asymptomatic COVID+ individuals with robust immune responses to SARS-CoV-2).