
Associate Professor
Primary Thematic Area
P_Bioengineering
Secondary Thematic Area
Research Summary
Engineering Molecular Technologies for Human Disease
+1 415 734-4058
Dr. Seth Shipman's research focuses on cellular systems in the midst of change. His lab seeks to better understand how the order of transcriptional events during development can drive changes in cell fate, and to better intervene in diseases characterized by change, like progressive neurodegeneration and cancer. His lab takes a molecular engineering approach, leveraging the versatility of DNA as a programmable biological polymer to gather data without destroying cells, and deliver therapeutics that can modify their effect based on cell context.
Websites
Publications
Retron reverse transcriptase termination and phage defense are dependent on host RNase H1.
Nucleic acids research
Precise genome editing across kingdoms of life using retron-derived DNA.
Nature chemical biology
One-step data storage in cellular DNA.
Nature chemical biology
High-throughput functional variant screens via in vivo production of single-stranded DNA.
Proceedings of the National Academy of Sciences of the United States of America