Seth Shipman, PhD

Assistant Professor
+1 415 734-4058
Research Description: 

Dr. Seth Shipman's research focuses on cellular systems in the midst of change. His lab seeks to better understand how the order of transcriptional events during development can drive changes in cell fate, and to better intervene in diseases characterized by change, like progressive neurodegeneration and cancer. His lab takes a molecular engineering approach, leveraging the versatility of DNA as a programmable biological polymer to gather data without destroying cells, and deliver therapeutics that can modify their effect based on cell context.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Engineering Molecular Technologies for Human Disease


Featured Publications: 

Recording gene expression order in DNA by CRISPR addition of retron barcodes.


Bhattarai-Kline S, Lear SK, Fishman CB, Lopez SC, Lockshin ER, Schubert MG, Nivala J, Church GM, Shipman SL

Retron reverse transcriptase termination and phage defense are dependent on host RNase H1.

Nucleic acids research

Palka C, Fishman CB, Bhattarai-Kline S, Myers SA, Shipman SL

Precise genome editing across kingdoms of life using retron-derived DNA.

Nature chemical biology

Lopez SC, Crawford KD, Lear SK, Bhattarai-Kline S, Shipman SL

One-step data storage in cellular DNA.

Nature chemical biology

Bhattarai-Kline S, Lear SK, Shipman SL

High-throughput functional variant screens via in vivo production of single-stranded DNA.

Proceedings of the National Academy of Sciences of the United States of America

Schubert MG, Goodman DB, Wannier TM, Kaur D, Farzadfard F, Lu TK, Shipman SL, Church GM