Saptarsi Haldar, MD, BS

Associate Investigator, Gladstone Institutes
Associate Professor of Medicine
Cardiovascular Division
+1 415 734-4058
Research Description: 

Clinical: I am a cardiologist specializing in general adult cardiology.

Research: I am a principal investigator at the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.

A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.

Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Gene Regulation and Epigenetics in Cardiovascular and Metabolic Physiology/Disease

Websites

Publications: 

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Circulation research

Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MP, Haldar SM, Lin CY, McKinsey TA

Epigenetic therapies in heart failure.

Journal of molecular and cellular cardiology

Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM

Drugging transcription in heart failure.

The Journal of physiology

Padmanabhan A, Haldar SM

Unusual transcription factor protects against heart failure.

Science (New York, N.Y.)

Padmanabhan A, Haldar SM

The Cardiac Myofibroblast.

Circulation research

Alexanian M, Haldar SM