Ryan Hernandez, PhD

Associate Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 514-9813
Research Overview: 

Hernandez Lab research focuses on three main areas:

  1. Basic population genomics: we seek to use current patterns of human genetic variation from whole genome sequencing to understand the evolutionary history of human populations.
  2. Disease susceptibility in complex populations: We strive to leverage evolutionary signals in patterns of genetic variation to uncover the meaningful associations with phenotypic variation.
  3. Host-pathogen interactions: We develop tools to leverage patterns of genetic diversity within populations and divergence across phylogenies to learn more about the genetic targets of host-pathogen interactions.
Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
None
Research Summary: 
We study patterns of human genetic variation using large-scale data and the tools of population genomics.
Publications: 

The Temporal Dynamics of Background Selection in Nonequilibrium Populations.

Genetics

Torres R, Stetter MG, Hernandez RD, Ross-Ibarra J

De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.

Proceedings of the National Academy of Sciences of the United States of America

Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O'Connell JR, Mitchell BD, O'Connor TD

Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity.

American journal of human genetics

Szpiech ZA, Mak ACY, White MJ, Hu D, Eng C, Burchard EG, Hernandez RD

Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.

Nature communications

Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo MI, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Gourraud PA, Hansel NN, Hernandez RD, Herrera-Paz EF, Jiménez S, Kenny EE, Knight-Madden J, Kumar R, Lange LA, Lange EM, Lizee A, Maul P, Maul T, Mayorga A, Meyers D, Nicolae DL, O'Connor TD, Oliveira RR, Olopade CO, Olopade O, Qin ZS, Rotimi C, Vince N, Watson H, Wilks RJ, Wilson JG, Salzberg S, Ober C, Burchard EG, Williams LK, Beaty TH, Taub MA, Ruczinski I, Mathias RA, Barnes KC