Ryan Hernandez, PhD

Associate Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 514-9813
Research Overview: 

Hernandez Lab research focuses on three main areas:

  1. Basic population genomics: we seek to use current patterns of human genetic variation from whole genome sequencing to understand the evolutionary history of human populations.
  2. Disease susceptibility in complex populations: We strive to leverage evolutionary signals in patterns of genetic variation to uncover the meaningful associations with phenotypic variation.
  3. Host-pathogen interactions: We develop tools to leverage patterns of genetic diversity within populations and divergence across phylogenies to learn more about the genetic targets of host-pathogen interactions.
Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Research Summary: 
We study patterns of human genetic variation using large-scale data and the tools of population genomics.
Mentorship Development: 

3/10/20    Promoting Student Mental Health:A Presentation and Discussion (Staff and Faculty)    
4/23/20    Effective Strategies for IDPs    
4/30/20    Mental Health in a Pandemic: Q&A for Faculty    
2/18/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels    
2/19/21    DEI Champions Training


Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits.


Spear ML, Diaz-Papkovich A, Ziv E, Yracheta JM, Gravel S, Torgerson DG, Hernandez RD

A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles.

Science translational medicine

Claesen J, Spagnolo JB, Ramos SF, Kurita KL, Byrd AL, Aksenov AA, Melnik AV, Wong WR, Wang S, Hernandez RD, Donia MS, Dorrestein PC, Kong HH, Segre JA, Linington RG, Fischbach MA, Lemon KP

The Temporal Dynamics of Background Selection in Nonequilibrium Populations.


Torres R, Stetter MG, Hernandez RD, Ross-Ibarra J

De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.

Proceedings of the National Academy of Sciences of the United States of America

Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O'Connell JR, Mitchell BD, O'Connor TD