Roshanak Irannejad, PhD

Asst Professor in Residence
Cardiovascular Research Inst
Research Overview: 

To function properly, cells and tissue must receive and interpret a large variety of signals through signaling receptors, some of which reside on cell surface. By developing a new class of biosensors, we made the unexpected finding that signaling cues to cells not only act on cell surface receptors but also on internal membrane compartments. This observation raises numerous questions pertaining to fundamental aspects of cell signaling but also provide insights into mechanisms of actions of some clinically-used drugs. The research in our lab is focused on organelle-based signaling and combines use of novel biosensors, sophisticated live cell imaging, biochemistry, pharmacology and physiology in cell lines and whole animals.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Organelle-based signaling in cardiovascular biology


Featured Publications: 

Functional selectivity of GPCR-directed drug action through location bias.

Nature chemical biology

Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M

The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor.

The Journal of biological chemistry

Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL

GPCR signaling along the endocytic pathway.

Current opinion in cell biology

Irannejad R, von Zastrow M

Conformational biosensors reveal GPCR signalling from endosomes.


Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M