Roberto Ricardo Gonzalez, MD, PhD

Assistant Professor
Department of Dermatology
Department of Microbiology and Immunology
Research Overview: 

Research on inflammatory diseases of the skin and other organ systems has led to therapeutics that mitigate chronic inflammation. However, how inflammation influences single cells at the tissue level to contribute to disease pathogenesis remains vastly unknown. Our goal is to decipher how inflammation affects not only the epithelial barrier, which can be a focal point of early disease pathology, but also dissect how other essential components of the tissue such as fibroblasts, endothelial cells, lymphatics, and others are individually affected during states of acute and chronic inflammation. We leverage our expertise in tissue biology, immunology, microscopy, and multi-omics analyses to perform assays that test physiologic functions of barrier tissues to uncover new insights into tissue homeostasis. In addition, we use models of adoptive transfer of ILCs to evaluate their therapeutic potential and determine how these cells can promote beneficial tissue inflammation or serve as adjuvant therapies against cancer. Finally, we aim to discover novel ways to manipulate detrimental immune-'niche' crosstalk to develop therapeutic interventions to ameliorate chronic inflammatory diseases.

Ongoing research efforts include:

  1. Elucidating how immune cells and their outputs alter tissue niche composition and molecular networks in homeostasis and disease.
  2. Dissecting molecular mechanisms of how type 2 immunity co-opts allergic and regenerative immune functions to preserve and protect tissue function from the detrimental effects of chronic pathogenic inflammation. 
  3. Exploring the use of innate lymphoid cells (ILCs) as adjuvant therapies to treat infection and cancer and understand principles of tissue residency and adaptation
Primary Thematic Area: 
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Decoding the role of allergic immunity in tissue health


Featured Publications: 

Tissue signals imprint ILC2 identity with anticipatory function.

Nature immunology

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM

Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.

The Journal of experimental medicine

Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM

Skin-resident innate lymphoid cells converge on a pathogenic effector state.


Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA

Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.


Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM