Raymond Swanson, MD

Professor in Residence
Department of Neurology
+1 415 750-2011
Research Description: 

Ray Swanson is a clinician-scientist with joint appointments in the UCSF Department of Neurology and the San Francisco Veterans Affairs Medical Center. His research explores bioenergetics and oxidative signaling in neurological disease. His studies in the area of stroke aim to identify ways to mitigate the dendritic and axonal ischemic injury, and in particular injury caused by neuronal NADPH oxidase and cofilin-actin rod formation. Work pertaining to Parkinson's disease aims to identify interactions between neuronal redox state and alpha-synuclein aggregation. This effort also involves pre-clinical and clinical studies of thiol repletion agents as a disease-modifying therapeutic approach. The Swanson laboratory is in the 1700 Owens St. building on the Mission Bay campus.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
Bioenergetics and oxidative signaling in neurological disease

Websites

Publications: 

Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement.

Scientific reports

Bishop R, Won SJ, Irvine KA, Basu J, Rome ES, Swanson RA

Glucose availability limits microglial nitric oxide production.

Journal of neurochemistry

Castillo E, Mocanu E, Uruk G, Swanson RA

a-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.

Progress in neurobiology

Ghosh S, Won SJ, Wang J, Fong R, Butler NJM, Moss A, Wong C, Pan J, Sanchez J, Huynh A, Wu L, Manfredsson FP, Swanson RA

A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling.

Proceedings of the National Academy of Sciences of the United States of America

Iwashita H, Castillo E, Messina MS, Swanson RA, Chang CJ

Reactive astrocyte nomenclature, definitions, and future directions.

Nature neuroscience

Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A