Ralph Marcucio, PhD

Professor
Department of Orthopaedic Surgery
+1 628 206-5366
Research Overview: 

First, using cutting-edge genomic technology, Dr. Marcucio is examining how the entire genome responds to orthopaedic trauma. This genome-mining approach is aimed at determining the global genome response during fracture repair and allows the possibility to generate improved, highly innovative therapies for people undergoing fracture repair. Second, Ralph is examining the role that the brain plays during normal development of the facial skeleton. Many facial birth defects have an underlying brain malformation, and the goal of the research is to generate novel therapeutic approaches that will allow correcting facial malformations prior to birth.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
None
Research Summary: 
Craniofacial development, evolutionary biology, trauma, bone repair, angiogenesis

Websites

Publications: 

CD47 is required for mesenchymal progenitor proliferation and fracture repair.

Bone research

Zondervan RL, Capobianco CA, Jenkins DC, Reicha JD, Fredrick L, Lam C, Schmanski JT, Isenberg JS, Ahn J, Marcucio RS, Hankenson KD

Quantifying the relationship between cell proliferation and morphology during development of the face.

Development (Cambridge, England)

Lo Vercio LD, Green RM, Dauter A, Barretto EC, Vidal-García M, Devine J, Marchini M, Robertson S, Zhao X, Mahika A, Shakir MB, Guo S, Boughner JC, Szabo-Rogers H, Dean W, Lander AD, Marcucio RS, Forkert ND, Hallgrímsson B

Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face.

bioRxiv : the preprint server for biology

Hanne N, Hu D, Vidal-García M, Allen C, Shakir MB, Liu W, Hallgrímsson B, Marcucio R

PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.

bioRxiv : the preprint server for biology

Mok CH, Hu D, Losa M, Risolino M, Selleri L, Marcucio RS