Assistant Professor
Primary Thematic Area
M_PEDS-NEPHROLOGY
Secondary Thematic Area
Research Summary
Drug discovery/repurposing and disease pathogenesis mechanisms for renal, gastrointestinal, and cardiovascular diseases.
Dr. Onur Cil is a pediatric nephrologist and physician-scientist. Cil Lab’s research focus is small molecule drug discovery and drug repurposing for treatment of renal, gastrointestinal and cardiovascular diseases. Ultimate goal of our research is advancing our discoveries to clinical trials and establishing better and safer treatments. Our research is focused on membrane proteins including calcium-sensing receptor (CaSR), SLC26A3 (DRA), SLC26A4 (Pendrin), SLC26A6 (PAT1), CFTR, TMEM16A and urea transporters.
Websites
Publications
Repurposing calcium sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas.
JCI insight
A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.
Kidney international
Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.
Journal of the American Society of Nephrology : JASN
CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.
Cellular and molecular gastroenterology and hepatology