Onur Cil, MD, PhD

Assistant Professor
Pediatrics
[email protected]
Research Description: 

Dr. Onur Cil is a pediatric nephrologist and physician-scientist. Cil Lab’s research focus is small molecule drug discovery and drug repurposing for treatment of renal, gastrointestinal and cardiovascular diseases. Ultimate goal of our research is advancing our discoveries to clinical trials and establishing better and safer treatments. Our research is focused on membrane proteins including calcium-sensing receptor (CaSR), SLC26A3 (DRA), SLC26A4 (Pendrin), SLC26A6 (PAT1), CFTR, TMEM16A and urea transporters.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Vascular & Cardiac Biology
Research Summary: 
Drug discovery/repurposing and disease pathogenesis mechanisms for renal, gastrointestinal, and cardiovascular diseases.

Websites

Featured Publications: 

A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.

Kidney international

Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Thwe PM, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS

Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.

Journal of the American Society of Nephrology : JASN

Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS

CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.

Cellular and molecular gastroenterology and hepatology

Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS

Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.

Kidney international

Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS