Michael Rosenblum, MD, PhD

Professor in Residence
Department of Dermatology
Research Overview: 

The central focus of my lab is to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. To this end, we currently have two areas of active investigation:

  1. Understanding how regulatory T cells (Tregs) control immune responses in tissues
  2. Understanding the ‘alternative’ functions of Tregs in tissues

Approach
Because of its complex immunological properties, its accessibility, and potential for clinical translation, the skin is the model peripheral tissue that we currently study. Approximately 50% of our research employs a reductionist approach, utilizing transgenic animal models to ask fundamental questions of how the immune system functions in skin at both the cellular and molecular levels. The other half of our work focuses on doing functional immunology with human skin, human blood and humanized mice.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
None
Research Summary: 
Defining the cellular and molecular mechanisms of immune regulation in peripheral tissues

Websites

Publications: 

Interleukin-2-induced skin inflammation.

European journal of immunology

Sommer C, Cohen JN, Dehmel S, Neuhaus V, Schaudien D, Braun A, Sewald K, Rosenblum MD

Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.

JCI insight

Lowe MM, Cohen JN, Moss MI, Clancy S, Adler JP, Yates AE, Naik HB, Yadav R, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM

Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.

Science immunology

Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD

Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.

bioRxiv : the preprint server for biology

Lowe MM, Cohen JN, Moss MI, Clancy S, Adler J, Yates A, Naik HB, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM

Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-a?? therapy.

JCI insight

Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD