Michael Rosenblum, MD, PhD

Assistant Professor
Department of Dermatology
Research Overview: 

The central focus of my lab is to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. To this end, we currently have two areas of active investigation:

  1. Understanding how regulatory T cells (Tregs) control immune responses in tissues
  2. Understanding the ‘alternative’ functions of Tregs in tissues

Approach
Because of its complex immunological properties, its accessibility, and potential for clinical translation, the skin is the model peripheral tissue that we currently study. Approximately 50% of our research employs a reductionist approach, utilizing transgenic animal models to ask fundamental questions of how the immune system functions in skin at both the cellular and molecular levels. The other half of our work focuses on doing functional immunology with human skin, human blood and humanized mice.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
None
Research Summary: 
Defining the cellular and molecular mechanisms of immune regulation in peripheral tissues

Websites

Publications: 

Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo.

Journal of immunology (Baltimore, Md. : 1950)

Pinheiro DF, Szenes-Nagy AB, Maurano MM, Lietzenmayer M, Klicznik MM, Holly R, Kirchmeier D, Kitzmueller S, Achatz-Straussberger G, Rosenblum MD, Thalhamer J, Abbas AK, Gratz IK

Layilin augments integrin activation to promote antitumor immunity.

The Journal of experimental medicine

Mahuron KM, Moreau JM, Glasgow JE, Boda DP, Pauli ML, Gouirand V, Panjabi L, Grewal R, Luber JM, Mathur AN, Feldman RM, Shifrut E, Mehta P, Lowe MM, Alvarado MD, Marson A, Singer M, Wells J, Jupp R, Daud AI, Rosenblum MD

Keepin' it regulatory: Foxp3 gets a BAFfling SWItch.

Science immunology

Kinet MJ, Rosenblum MD

Contribution of plasma cells and B-cells to hidradenitis suppurativa pathogenesis.

JCI insight

Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen AR, Zee HH, Harms PW, Wasikowski R, Yee CM, Rizvi SM, Xing X, Xing E, Plazyo O, Zeng C, Patrick MT, Lowe MM, Burney RE, Kozlow JH, Cherry-Bukowiec JR, Jiang Y, Kirma J, Weidinger S, Cushing KC, Rosenblum MD, Berthier CC, MacLeod AS, Voorhees JJ, Wen F, Kahlenberg JM, Maverakis E, Modlin RL, Prens EP

Immunopathogenesis of hidradenitis suppurativa and response to anti-TNFa therapy.

JCI insight

Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson J, Paul M, Harris HW, Kim EA, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum M