Mercedes Paredes, MD, PhD

Asst Professor in Residence
Neurology
Research Overview: 

The Paredes lab studies cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy, and brain malformations. Our hypothesis is that the gyrencephalic brain has evolved developmental processes and a prolonged timeline that, when disrupted, will lead to cortical disorganization and aberrant connectivity. We are currently focused on identifying features of neuronal progenitor proliferation and migration, with an emphasis on the perinatal period, that are unique to the gyrated brain. Our approach is to advance ways to directly investigate the human brain and to better model its development using gyrencephalic systems like the piglet cortex.

Migratory neurons in piglet brain

 

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
Studying cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy and brain malformations.
Publications: 

Implications of Extended Inhibitory Neuron Development.

International journal of molecular sciences

Kim JY, Paredes MF

Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A

Interneuron origins in the embryonic porcine medial ganglionic eminence.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC

Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.

Cell reports

Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.

eLife

Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz J, Vogt D, Paredes MF, Rubenstein JL