Mercedes Paredes, MD, PhD

Assoc Professor in Residence
Neurology
Research Overview: 

The Paredes lab studies cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy, and brain malformations. Our hypothesis is that the gyrencephalic brain has evolved developmental processes and a prolonged timeline that, when disrupted, will lead to cortical disorganization and aberrant connectivity. We are currently focused on identifying features of neuronal progenitor proliferation and migration, with an emphasis on the perinatal period, that are unique to the gyrated brain. Our approach is to advance ways to directly investigate the human brain and to better model its development using gyrencephalic systems like the piglet cortex.

Migratory neurons in piglet brain

 

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
Studying cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy and brain malformations.
Publications: 

Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Science (New York, N.Y.)

Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Garcia-Verdugo JM, Yang Z, Huang EJ

The development and evolution of inhibitory neurons in primate cerebrum.

Nature

Schmitz MT, Sandoval K, Chen CP, Mostajo-Radji MA, Seeley WW, Nowakowski TJ, Ye CJ, Paredes MF, Pollen AA

Amplification of human interneuron progenitors promotes brain tumors and neurological defects.

Science (New York, N.Y.)

Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA

Nests of dividing neuroblasts sustain interneuron production for the developing human brain.

Science (New York, N.Y.)

Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano J, Vento M, Scott J, Studholme C, Nowakowski TJ, Kriegstein AR, Oldham MC, Hasenstaub A, Garcia-Verdugo JM, Alvarez-Buylla A, Huang EJ

Implications of Extended Inhibitory Neuron Development.

International journal of molecular sciences

Kim JY, Paredes MF