Mercedes Paredes, MD, PhD

Asst Professor in Residence
Neurology
Research Overview: 

The Paredes lab studies cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy, and brain malformations. Our hypothesis is that the gyrencephalic brain has evolved developmental processes and a prolonged timeline that, when disrupted, will lead to cortical disorganization and aberrant connectivity. We are currently focused on identifying features of neuronal progenitor proliferation and migration, with an emphasis on the perinatal period, that are unique to the gyrated brain. Our approach is to advance ways to directly investigate the human brain and to better model its development using gyrencephalic systems like the piglet cortex.

Migratory neurons in piglet brain

 

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
Studying cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy and brain malformations.
Publications: 

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.

eLife

Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz J, Vogt D, Paredes MF, Rubenstein JL

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.

Nature neuroscience

Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH

Cortical Malformations: Lessons in Human Brain Development.

Frontiers in cellular neuroscience

Subramanian L, Calcagnotto ME, Paredes MF

Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.

Brain Communications

Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML

Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.

Brain Communications

Zachary A Miller, Salvatore Spina, Mikhail Pakvasa, Lynne Rosenberg, Christa Watson, Maria Luisa Mandelli, Mercedes F Paredes, Renaud La Joie, Gil D Rabinovici, Howard J Rosen, Lea T Grinberg, Eric J Huang, Bruce L Miller, William W Seeley, Maria Luisa Gorno-Tempini